64118-86-1
Chemical Structure
Azimexon
Synonym(s): BM 12.531
- CAS No.: 64118-86-1
- Formula:C9H14N4O
- Molecular Weight:194.23
InChIKey: RPZOFMHRRHHDPZ-UHFFFAOYSA-N
SMILES: N#CC1N(C(C)(C)N2CC2C(N)=O)C1
Biological Activity: Azimexon (BM 12.531) is an orally active immunomodulator with radioprotective and antitumor activities. Azimexon prolongs survival in multiple mouse models, enhances immunity and hematopoiesis, and alleviates radiation injury and tumor metastasis. Azimexon causes reversible hemolytic anemia in rats and dogs, and exerts therapeutic activity against adjuvant-induced arthritis in rats. Azimexon can be used for the research of lung carcinoma, leukemia, multiple myeloma, lung tumor, arthritis, breast cancer and AIDS‑related complex[1][2][3].
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Azimexon | Azimexon (BM 12.531) is an orally active immunomodulator with radioprotective and antitumor activities. Azimexon prolongs survival in multiple mouse models, enhances immunity and hematopoiesis, and alleviates radiation injury and tumor metastasis. Azimexon causes reversible hemolytic anemia in rats and dogs, and exerts therapeutic activity against adjuvant-induced arthritis in rats. Azimexon can be used for the research of lung carcinoma, leukemia, multiple myeloma, lung tumor, arthritis, breast cancer and AIDS‑related complex. | |||||||||||||||||||||
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- [1]. Stylos WA, et al. The immunomodulatory effect on BM 12.531 (azimexon) on normal or tumored mice: in vitro and in vivo studies. J Immunopharmacol. 1980;2(1):113-132. [Content Brief]
- [2]. Peter HH, et al. The effect of BM 12.531 (azimexon) on natural killer cell activity in myeloma patients. Eur J Cancer Clin Oncol. 1984;20(3):353-359. [Content Brief]
- [3]. Remers WA, et al. Chemistry and pharmacology of imexon and related cyanoaziridines. Curr Med Chem. 2012;19(33):5745-53. [Content Brief]
Keywords
