Kijimicin
Kijimicin is a polyether ionophore antibiotic originally discovered in Actinomadura sp. MI215-NF3. inhibits HIV-1 replication and reduces the infectivity of progeny viral particles. Kijimicin exhibits inhibitory activity against intracellular T. gondii (IC50 = 45.6 nM), extracellular parasites (IC50 = 216.6 pM) and C. parvum (IC50 = 7.7 nM), and controls acute T. gondii infection in mice. Kijimicin can be used for research on HIV, toxoplasmosis, cryptosporidiosis, and bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 129297-22-9
- Formula: C37H64O11
- Molecular Weight:684.90
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
HIV-1 2.2 μg/mL (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HFF | IC50 |
46.5 μM
|
Exhibits low cytotoxicity against HFF cells.
Exhibits low cytotoxicity against HFF cells.
|
books/R100000039-I11123919 |
| HCT-8 | CC50 |
> 20 μM
|
Shows no significant cytotoxicity in HCT-8.
Shows no significant cytotoxicity in HCT-8.
|
42075832 |
Kijimicin (7 days) inhibits HIV-1 replication in acutely infected H9 cells with an IC50 of 2.2 μg/mL, and shows little cytotoxicity (IC50 = 88 μg/mL)[1].
Kijimicin (0.1-1000 μg/mL; 72 h) inhibits HIV-1 replication in chronically infected U937 cells[1].
Kijimicin (0.01, 0.1, 1.0 μg/mL; 7 days) reduces the infectivity of progeny HIV-1 viral particles from H9 cells by more than 1 log[1].
Kijimicin exhibits antimicrobial activity against Gram-positive bacteria including Staphylococcus aureus FDA 209P (MIC < 0.78 μg/mL), Bacillus cereus ATCC 10702 (MIC < 0.78 μg/mL), and Micrococcus luteus PCI 1001 (MIC < 0.78 μg/mL)[2].
Kijimicin (7.7 nM; 48 h) inhibits C. parvum growth in HCT-8 cells with an IC50 of 7.7 nM and a CC50 > 20 μM (selectivity index = 2585)[3].
Kijimicin (1-300 nM; 72 h) inhibits intracellular T. gondii RH-GFP growth in HFF cells with an IC50 of 45.6 nM and a selectivity index of 1019.7[4].
Kijimicin (1-2000 pM; 1 h) inhibits extracellular T. gondii RH-GFP invasion into Vero cells with an IC50 of 216.6 pM and a selectivity index of 214,681.4[4].
Kijimicin (50 nM; 24 h) induces morphological changes in T. gondii tachyzoites, including cell swelling and multiple intracellular vacuole-like structures[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HFF cells
-
Concentration:100 nM to 300 μM
-
Incubation Time:72 h
-
Result:Showed an IC50 of 46.5 μM.
-
Cell Line:HFF cells infected with T. gondii RH-GFP
-
Concentration:1, 3, 10, 30, 100, 300 nM
-
Incubation Time:72 h
-
Result:Inhibited intracellular T. gondii growth with IC50 of 45.6 nM and SI of 1019.7.
-
Cell Line:Vero cells
-
Concentration:1, 3, 10, 30, 100, 300, 1000, 2000 pM
-
Incubation Time:1 h pretreatment + 24 h post-infection
-
Result:Inhibited T. gondii invasion into Vero cells with IC50 of 216.6 pM and SI of 214,681.4.
-
Cell Line:Vero cells infected with T. gondii RH-GFP
-
Concentration:50 nM
-
Incubation Time:24 h
-
Result:Induced morphological changes in tachyzoites including cell swelling and vacuole-like structures.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:T. gondii PLK-GFP-infected female BALB/c mice (6-8 weeks old)[4]
-
Dosage:3, 10 mg/kg
-
Administration:i.p.; once daily for 7 days
-
Result:Improved survival rate (91.7%) and reduced clinical signs from 7 to 17 days post-infection(10 mg/kg).
Improved survival rate (66.7%) and reduced clinical signs.
Chemical Information
-
CAS No. 129297-22-9
-
Molecular Weight 684.90
-
Formula C37H64O11
-
SMILES
C[C@H](C([C@H](C)[C@@H](OC)[C@H]1C)O[C@]21CC[C@@H]([C@H]3CC[C@@](O3)([C@@H]4O[C@@H]([C@@]5(O)O[C@](C[C@@H]5C)(C)[C@H](O)CC)C[C@@H]4C)C)O2)[C@@H](OC)[C@H](C)C(O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yamauchi T, et al. Mechanistic effects of kijimicin on inhibition of human immunodeficiency virus replication. Mol Cell Biochem. 1993 Feb 17;119(1-2):35-41. [Content Brief]
[2]. Takahashi Y, et al. Kijimicin, a polyether antibiotic. J Antibiot (Tokyo). 1990 Apr;43(4):441-3. [Content Brief]
[3]. Kubota R, et al. Development of a Luciferase-Based In Vitro Assay to Evaluate the Efficacy of Anti-Cryptosporidial Drugs Against Cryptosporidium parvum. Pharmaceuticals (Basel). 2026 Apr 3;19(4):576. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kijimicin Related Classifications
HY-123444 Related Classifications
Powered by Bioz
- Kijimicin
- 129297-22-9
- Antibiotic
- HIV
- Reverse Transcriptase
- Parasite
- Bacterial
- polyether ionophore
- antibiotic
- HIV-1
- antiviral
- anti-HIV
- reverse transcriptase
- Toxoplasma gondii
- anti-Toxoplasma
- Cryptosporidium parvum
- anti-Cryptosporidium
- Apicomplexa
- antiparasitic
- anticoccidial
- Eimeria tenella
- Actinomadura
- Inhibitor
- inhibitor
- inhibit