129297-22-9
Chemical Structure
Kijimicin
- CAS. Nr.: 129297-22-9
- Formula:C37H64O11
- Molecular Weight:684.90
IUPAC Name: (2S,3R,4S)-4-((2S,5R,8R,9R,10R)-2-((2R,2'R,2''S,3'S,3''S,5R,5'R,5''S)-2''-hydroxy-5''-((R)-1-hydroxypropyl)-2,3',3'',5''-tetramethyldodecahydro-[2,2':5',2''-terfuran]-5-yl)-9-methoxy-8,10-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)-3-methoxy-2-methylpentanoic acid
InChIKey: DQQFPJYHEYSNAS-AQXRJQSRSA-N
SMILES: C[C@H](C([C@H](C)[C@@H](OC)[C@H]1C)O[C@]21CC[C@@H]([C@H]3CC[C@@](O3)([C@@H]4O[C@@H]([C@@]5(O)O[C@](C[C@@H]5C)(C)[C@H](O)CC)C[C@@H]4C)C)O2)[C@@H](OC)[C@H](C)C(O)=O
Biological Activity: Kijimicin is a polyether ionophore antibiotic originally discovered in Actinomadura sp. MI215-NF3. inhibits HIV-1 replication and reduces the infectivity of progeny viral particles. Kijimicin exhibits inhibitory activity against intracellular T. gondii (IC50 = 45.6 nM), extracellular parasites (IC50 = 216.6 pM) and C. parvum (IC50 = 7.7 nM), and controls acute T. gondii infection in mice. Kijimicin can be used for research on HIV, toxoplasmosis, cryptosporidiosis, and bacterial infections[1][2][3][4].
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Kijimicin | Kijimicin is a polyether ionophore antibiotic originally discovered in Actinomadura sp. MI215-NF3. inhibits HIV-1 replication and reduces the infectivity of progeny viral particles. Kijimicin exhibits inhibitory activity against intracellular T. gondii (IC50 = 45.6 nM), extracellular parasites (IC50 = 216.6 pM) and C. parvum (IC50 = 7.7 nM), and controls acute T. gondii infection in mice. Kijimicin can be used for research on HIV, toxoplasmosis, cryptosporidiosis, and bacterial infections. | |||||||||||||||||||||
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References
- [1]. Yamauchi T, et al. Mechanistic effects of kijimicin on inhibition of human immunodeficiency virus replication. Mol Cell Biochem. 1993 Feb 17;119(1-2):35-41. [Content Brief]
- [2]. Takahashi Y, et al. Kijimicin, a polyether antibiotic. J Antibiot (Tokyo). 1990 Apr;43(4):441-3. [Content Brief]
- [3]. Kubota R, et al. Development of a Luciferase-Based In Vitro Assay to Evaluate the Efficacy of Anti-Cryptosporidial Drugs Against Cryptosporidium parvum. Pharmaceuticals (Basel). 2026 Apr 3;19(4):576. [Content Brief]
- [4]. Leesombun, et al. Efficacy of piperaceae plant extracts and microorganism-derived compounds: metacytofilin and kijimicin against Toxoplasma gondii, 帯広畜産大学, 2017-09-29.
