149607-21-6
Chemical Structure
U 92163
- CAS No.: 149607-21-6
- Formula:C34H51N5O5
- Molecular Weight:609.81
IUPAC Name: (S)-N1-((2S,3S,5S)-1-cyclohexyl-3-hydroxy-6-methyl-5-(neopentylcarbamoyl)heptan-2-yl)-2-(quinoline-2-carboxamido)succinamide
InChIKey: YFPJVAMWHSOWMB-JSRHHAARSA-N
SMILES: C(N[C@H](C(N[C@@H](CC1CCCCC1)[C@H](C[C@H](C(NCC(C)(C)C)=O)[C@H](C)C)O)=O)CC(N)=O)(=O)C2=NC3=C(C=C2)C=CC=C3
Biological Activity: U 92163 is an HIV-2 protease inhibitor. It is a synthetic peptidomimetic transition-state analog. U 92163 binds in an extended conformation along the length of the enzyme's binding cleft, and forms hydrogen bonds with the catalytic aspartate pair and other protease residues to block enzyme activity. U 92163 can be used in research on acquired immunodeficiency syndrome (AIDS)[1].
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U 92163 | U 92163 is an HIV-2 protease inhibitor. It is a synthetic peptidomimetic transition-state analog. U 92163 binds in an extended conformation along the length of the enzyme's binding cleft, and forms hydrogen bonds with the catalytic aspartate pair and other protease residues to block enzyme activity. U 92163 can be used in research on acquired immunodeficiency syndrome (AIDS). | |||||||||||||||||||||
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