PTP1B-IN-33
PTP1B-IN-33 is a PTP1B inhibitor with a human IC50 of 2.45 μM and over 20-fold selectivity for PTP1B over SHP2. PTP1B-IN-33 enhances π-Alkyl interaction with PTP1B to increase WPD loop closure degree. PTP1B-IN-33 can be used for the research of cancer, diabetes, autoimmune deficiency diseases.
For research use only. We do not sell to patients.
- CAS No.: 77500-30-2
- Formula: C18H14N2O3
- Molecular Weight:306.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PTP1B-IN-33 (compound Q1) induces a higher degree of WPD loop closure (5.4 Å) in human PTP1B than in human SHP2PTP (1.2 Å), enhancing PTP1B stability through strong interactions with the pTyr loop residue R47[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 77500-30-2
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Molecular Weight 306.32
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Formula C18H14N2O3
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SMILES
O=C(C1=CC=C(O1)C(NC2=CC=CC=C2)=O)NC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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