163435-77-6
Chemical Structure
R-95845
- CAS. Nr.: 163435-77-6
- Formula:C17H16Br2N2O2
- Molecular Weight:440.14
IUPAC Name: (S)-2-((2-acetyl-5-methylphenyl)amino)-2-(2,6-dibromophenyl)acetamide
InChIKey: FELUFXCUIYHAPB-INIZCTEOSA-N
SMILES: [C@@H](NC1=C(C(C)=O)C=CC(C)=C1)(C(N)=O)C2=C(Br)C=CC=C2Br
Biological Activity: R-95845 is a non-nucleoside HIV-1 reverse transcriptase (RT) inhibitor. R-95845 is specific to HIV-1 RT and acts as a functionally non-competitive inhibitor with respect to nucleotide incorporation. R-95845 binds to the non-nucleoside inhibitor binding pocket of HIV-1 RT in a butterfly-like conformation, forms hydrogen bonds with Tyr 188 and Val 189, and engages in hydrophobic interactions with surrounding residues. R-95845 can be used in studies related to HIV-1 infection and acquired immunodeficiency syndrome[1][2][3].
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R-95845 | R-95845 is a non-nucleoside HIV-1 reverse transcriptase (RT) inhibitor. R-95845 is specific to HIV-1 RT and acts as a functionally non-competitive inhibitor with respect to nucleotide incorporation. R-95845 binds to the non-nucleoside inhibitor binding pocket of HIV-1 RT in a butterfly-like conformation, forms hydrogen bonds with Tyr 188 and Val 189, and engages in hydrophobic interactions with surrounding residues. R-95845 can be used in studies related to HIV-1 infection and acquired immunodeficiency syndrome. | |||||||||||||||||||||
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- [1]. Ding J, et al. Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors. Nature structural biology. 1995 May;2(5):407-15. [Content Brief]
- [2]. Ding J, et al. Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution. Structure. 1995 Apr 15;3(4):365-79.
- [3]. Quiñones-Mateu ME, et al. Characterization of the reverse transcriptase of a human immunodeficiency virus type 1 group O isolate. Virology. 1997 Sep 29;236(2):364-73.
Keywords
