157381-55-0
Chemical Structure
Rpi-856 C
- CAS. Nr.: 157381-55-0
- Formula:C39H56N6O10
- Molecular Weight:768.90
IUPAC Name: (3-(2-(2-(2-amino-3-methylbutanamido)-2-(3,5-dihydroxyphenyl)acetamido)-4-methylpentanamido)-2-oxo-4-phenylbutanoyl)valylvaline
InChIKey: VRJLRNCZYOXNGS-BHBQUVKGSA-N
SMILES: O=C([C@H](C(C)C)NC([C@H](C(C)C)NC(C(C(CC1=CC=CC=C1)NC([C@H](CC(C)C)NC(C(C2=CC(O)=CC(O)=C2)NC([C@H](C(C)C)N)=O)=O)=O)=O)=O)=O)O
Biological Activity: Rpi-856 C is an Aspartic protease inhibitor, with an IC50 of 5.5 nM against HIV-1 protease, 9.2 nM against HTLV-I protease, 2.0 μM against Cathepsin D, and 4.8 μM against Pepsin. Rpi-856 C is produced by the Streptomyces strain AL-322. Rpi-856 C does not inhibit chymosin, trypsin, chymotrypsin, papain, bromelain, thermolysin, prolyl endopeptidase, carboxypeptidase A or carboxypeptidase B. Rpi-856 C can be used in the research of acquired immunodeficiency syndrome (AIDS) and related diseases, as well as HIV infection[1][2][3].
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Rpi-856 C | Rpi-856 C is an Aspartic protease inhibitor, with an IC50 of 5.5 nM against HIV-1 protease, 9.2 nM against HTLV-I protease, 2.0 μM against Cathepsin D, and 4.8 μM against Pepsin. Rpi-856 C is produced by the Streptomyces strain AL-322. Rpi-856 C does not inhibit chymosin, trypsin, chymotrypsin, papain, bromelain, thermolysin, prolyl endopeptidase, carboxypeptidase A or carboxypeptidase B. Rpi-856 C can be used in the research of acquired immunodeficiency syndrome (AIDS) and related diseases, as well as HIV infection. | |||||||||||||||||||||
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References
- [1]. Asano T, et al. Novel retrovirus protease inhibitors, RPI-856 A, B, C and D, produced by Streptomyces sp. AL-322. J Antibiot (Tokyo). 1994 May;47(5):557-65.
- [2]. Kitazaki T, et al. Synthesis and human immunodeficiency virus (HIV)-1 protease inhibitory activity of tripeptide analogues containing a dioxoethylene moiety. Chemical & pharmaceutical bulletin. 1994 Dec;42(12):2636-40.
- [3]. Huh, et al. Anti-Obesitic Effects of Cathepsin S Inhibitory Fraction Derived from Paecilomyces Tenuipes in Mice Fed a High-Fat Diet. 2009.
