1. Anti-infection
  2. HIV

Doravirine (Synonyms: MK-1439)

Cat. No.: HY-16767 Purity: >98.0%
Handling Instructions

Doravirine is a novel non-nucleoside inhibitor of HIV-1 reverse transcriptase with potent activity against wild-type virus (95% inhibitory concentration 19 nM, 50% human serum).

For research use only. We do not sell to patients.

Doravirine Chemical Structure

Doravirine Chemical Structure

CAS No. : 1338225-97-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 270 In-stock
Estimated Time of Arrival: December 31
2 mg USD 168 In-stock
Estimated Time of Arrival: December 31
5 mg USD 288 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Doravirine is a novel non-nucleoside inhibitor of HIV-1 reverse transcriptase with potent activity against wild-type virus (95% inhibitory concentration 19 nM, 50% human serum). target:HIV [1] In vitro: Doravirine exhibits potent antiviral activity against wild-type virus and K103N, Y181C, and K103N/Y181C mutant viruses, with IC50 value of 12, 21, 31, and 33 nM, respectively. [1] MK-1439 exhibited similar antiviral activities against 10 different HIV-1 subtype viruses (a total of 93 viruses).[2] In vivo: Administration of 50 mg doravirine with a high-fat meal is associated with slight elevations in AUC time zero to infinity (AUC0-∞) and C24 h with no change in Cmax. Midazolam AUC0-∞ is slightly reduced by coadministration of doravirine (geometric mean ratio 0.82, 90% CI 0.70, 0.97). [3]

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (70.46 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3488 mL 11.7440 mL 23.4880 mL
5 mM 0.4698 mL 2.3488 mL 4.6976 mL
10 mM 0.2349 mL 1.1744 mL 2.3488 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

425.75

Formula

C₁₇H₁₁ClF₃N₅O₃

CAS No.

1338225-97-0

SMILES

N#CC1=CC(OC2=C(C(F)(F)F)C=CN(CC(N3C)=NNC3=O)C2=O)=CC(Cl)=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Doravirine
Cat. No.:
HY-16767
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Doravirine

Cat. No.: HY-16767