207736-05-8
Chemical Structure
CI-1029
- CAS No.: 207736-05-8
- Formula:C28H37NO4S
- Molecular Weight:483.66
IUPAC Name: (S)-6-(4-aminophenethyl)-3-((2-(tert-butyl)-4-(hydroxymethyl)-5-methylphenyl)thio)-4-hydroxy-6-isopropyl-5,6-dihydro-2H-pyran-2-one
InChIKey: ZUBPKHVCBGWWGO-NDEPHWFRSA-N
SMILES: NC(C=C1)=CC=C1CC[C@]2(CC(O)=C(C(O2)=O)SC3=C(C=C(C(C)=C3)CO)C(C)(C)C)C(C)C
Biological Activity: CI-1029 is a HIV-1 protease inhibitor with a human IC50 of 0.11 nM. CI-1029 inhibits both wild-type and mutant HIV proteases, and exhibits antiviral activity against HIV and multiple drug-resistant HIV strains, with an EC50 of 6.31 μM in the presence of 30% human serum. CI-1029 can be used in studies related to HIV infection and acquired immunodeficiency syndrome (AIDS)[1].
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CI-1029 | CI-1029 is a HIV-1 protease inhibitor with a human IC50 of 0.11 nM. CI-1029 inhibits both wild-type and mutant HIV proteases, and exhibits antiviral activity against HIV and multiple drug-resistant HIV strains, with an EC50 of 6.31 μM in the presence of 30% human serum. CI-1029 can be used in studies related to HIV infection and acquired immunodeficiency syndrome (AIDS). | |||||||||||||||||||||
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Keywords
