Cremophor EL-10
Cremophor EL-10 is a nonionic polyoxyethylene castor oil surfactant with multiple functions including organic solubilizer, mixed zinc anode corrosion inhibitor and dendrite growth inhibitor. By forming a physical barrier to block electrolyte contact and constructing oriented hydration channels to reduce the desolvation energy barrier of Zn2+ , Cremophor EL-10 achieves a corrosion inhibition efficiency of over 99%. Cremophor EL-10 exerts no significant effects on the mitochondrial activity and cell viability of epithelial cells, making it suitable for in vitro drug delivery and biopharmaceutical research at concentrations ≤10% v/v. However, Cremophor EL-10 may induce sustained non-endothelium-dependent contraction in rat aortic rings and exert concentration-dependent inhibitory effects on acetylcholine-induced endothelium-dependent relaxation responses.
For research use only. We do not sell to patients.
- CAS No.: 61791-12-6
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Cremophor EL-10 (100-500 mg/L; 6 h) potently inhibits static corrosion of pure zinc plates in 6 M KOH solution, achieving >90% inhibition efficiency at 100 mg/L and reaching a near-maximum inhibition efficiency near 98% at concentrations ≥400 mg/L after 6 h immersion[3].
Cremophor EL-10 (400 mg/L; 6 h) adsorbs onto pure zinc plates in 6 M K+OH? solution at 400 mg/L after 6 h immersion, forming a surface film composed of its molecular components as confirmed by characteristic ATR-FTIR peaks[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 61791-12-6
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SMILES
[Cremophor EL-10]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. MacDonald C, et al. Water-soluble organic solubilizers for in vitro drug delivery studies with respiratory epithelial cells: selection based on various toxicity indicators. Drug Deliv. 2010;17(6):434-442. [Content Brief]
[2]. Zengil H, et al. Effects of polysorbates and Cremophor EL on vascular responses in rat aorta. Experientia. 1995;51(11):1055-1059. [Content Brief]
[3]. Cen H, et al. Nonlinear Correlation of Polyoxyethylene Castor Oil between Dynamic-Static Corrosion Inhibition and Cyclic Stability as Zinc-Air Battery Additives. Langmuir. 2026;42(1):1627-1643. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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