1. Metabolic Enzyme/Protease
  2. Glucokinase
  3. Dorzagliatin

Dorzagliatin (Synonyms: HMS5552)

Cat. No.: HY-109030 Purity: 99.68%
Handling Instructions

Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes.

For research use only. We do not sell to patients.

Dorzagliatin Chemical Structure

Dorzagliatin Chemical Structure

CAS No. : 1191995-00-2

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10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 320 In-stock
Estimated Time of Arrival: December 31
50 mg USD 500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes[1].

IC50 & Target

Glucokinase[1]

In Vivo
Molecular Weight

462.93

Formula

C₂₂H₂₇ClN₄O₅

CAS No.

1191995-00-2

SMILES

O=C(NC1=NN(C[[email protected]@H](O)CO)C=C1)[[email protected]@H](N2CC(OC(C=CC=C3)=C3Cl)=CC2=O)CC(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (270.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1602 mL 10.8008 mL 21.6015 mL
5 mM 0.4320 mL 2.1602 mL 4.3203 mL
10 mM 0.2160 mL 1.0801 mL 2.1602 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.49 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.49 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.49 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.68%

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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DorzagliatinHMS5552HMS 5552HMS-5552GlucokinaseHexokinase IVHexokinase Dglycaemicpancreaticβ-celltype 2diabetesInhibitorinhibitorinhibit

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Product Name:
Dorzagliatin
Cat. No.:
HY-109030
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