1361217-07-3
Chemical Structure
AMG-1694
- CAS No.: 1361217-07-3
- Formula:C23H30F3N3O4S2
- Molecular Weight:533.63
IUPAC Name: (R)-1,1,1-trifluoro-2-(4-((S)-2-(((S)-3-methylmorpholino)methyl)-4-(thiophen-2-ylsulfonyl)piperazin-1-yl)phenyl)propan-2-ol
InChIKey: OJTJLEFGCNYTBQ-RBDMOPTHSA-N
SMILES: C[C@@](O)(C1=CC=C(N2[C@@H](CN3[C@@H](C)COCC3)CN(S(=O)(C4=CC=CS4)=O)CC2)C=C1)C(F)(F)F
Biological Activity: AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
AMG-1694 | AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
