1. Metabolic Enzyme/Protease
  2. Glucokinase
  3. AMG-1694

AMG-1694 

Cat. No.: HY-12614
Handling Instructions

AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals.

For research use only. We do not sell to patients.

AMG-1694 Chemical Structure

AMG-1694 Chemical Structure

CAS No. : 1361217-07-3

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Description

AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals[1].

IC50 & Target

IC50: 7 nM (GK-GKRP)[1]

In Vitro

AMG-1694 is highly effective in restoring the enzymatic activity of GK with an EC50 of 0.020 μM in the presence of GKRP[1].

Molecular Weight

533.63

Formula

C₂₃H₃₀F₃N₃O₄S₂

CAS No.

1361217-07-3

SMILES

C[[email protected]@](O)(C1=CC=C(N2[[email protected]@H](CN3[[email protected]@H](C)COCC3)CN(S(=O)(C4=CC=CS4)=O)CC2)C=C1)C(F)(F)F

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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AMG-1694
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HY-12614
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