1. Metabolic Enzyme/Protease
  2. Glucokinase
  3. RO-28-1675

RO-28-1675 

Cat. No.: HY-10595 Purity: 99.95%
COA Handling Instructions

RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes.

For research use only. We do not sell to patients.

RO-28-1675 Chemical Structure

RO-28-1675 Chemical Structure

CAS No. : 300353-13-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 284 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 284 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 258 In-stock
Estimated Time of Arrival: December 31
10 mg USD 444 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE RO-28-1675

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes[1][2].

IC50 & Target

EC50: 54 nM (glucokinase)[1]

In Vitro

RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RO-28-1675 (50 mg/kg; p.o.) reduces blood glucose levels in wild-type C57BL/6J mice[2].
RO-28-1675 exhibits high oral bioavailability (mice 92.8%) and Cmax (1140 μg/mL) following oral administration (10 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10 weeks old male C57BL/6J mice[2]
Dosage: 50 mg/kg
Administration: Oral administration
Result: Reduced blood glucose levels.
Animal Model: C57BL/6J mice[1]
Dosage: 10 mg/kg (Pharmacokinetic Analysis
Administration: Oral administration
Result: Oral bioavailability (92.8%), Cmax (1140 μg/mL), T max (3.3 h).
Molecular Weight

378.51

Formula

C18H22N2O3S2

CAS No.
SMILES

O=C([[email protected]@H](C1=CC=C(C=C1)S(=O)(C)=O)CC2CCCC2)NC3=NC=CS3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (132.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6419 mL 13.2097 mL 26.4194 mL
5 mM 0.5284 mL 2.6419 mL 5.2839 mL
10 mM 0.2642 mL 1.3210 mL 2.6419 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.60 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.60 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.60 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.95%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
RO-28-1675
Cat. No.:
HY-10595
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