1. Metabolic Enzyme/Protease
  2. Glucokinase
  3. Ro 28-1675

Ro 28-1675 

Cat. No.: HY-10595 Purity: 99.41%
Handling Instructions

Ro 28-1675 (Ro 0281675) is a potent allosteric GK activator with a SC1.5 value of 0.24± 0.0019 uM.

For research use only. We do not sell to patients.

Ro 28-1675 Chemical Structure

Ro 28-1675 Chemical Structure

CAS No. : 300353-13-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 284 In-stock
Estimated Time of Arrival: December 31
5 mg USD 258 In-stock
Estimated Time of Arrival: December 31
10 mg USD 444 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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Description

Ro 28-1675 (Ro 0281675) is a potent allosteric GK activator with a SC1.5 value of 0.24± 0.0019 uM. IC50 value: 0.24± 0.0019 uM (SC1.5) [1] Target: Glucokinase activator The R stereoisomer Ro 28-1675 activated GK with a SC1.5 of 0.24 uM, while the S isomer did not activated GK up to 10 uM. Oral administration of Ro 28-1675 (50 mg/Kg) to male C57B1/6J mice caused a statistically significant reduction in fasting glucose levels and improvement in glucose tolerance relative to the vehicle treated animals [1]. Comparison of rat PK parameters indicated that Ro 28-1675 displayed lower clearance and higher oral bioavailability compared to 9a. Following a single oral dose, Ro 28-1675 reduced fasting and postprandial glucose levels following an OGTT, was well tolerated, and displayed no adverse effects related to drug administration other than hypoglycemia at the maximum dose (400 mg). [1]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (132.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6419 mL 13.2097 mL 26.4194 mL
5 mM 0.5284 mL 2.6419 mL 5.2839 mL
10 mM 0.2642 mL 1.3210 mL 2.6419 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.60 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.60 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.60 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

378.51

Formula

C₁₈H₂₂N₂O₃S₂

CAS No.

300353-13-3

SMILES

O=C(NC1=NC=CS1)[[email protected]](CC2CCCC2)C3=CC=C(S(=O)(C)=O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.41%

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Product Name:
Ro 28-1675
Cat. No.:
HY-10595
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Ro 28-1675

Cat. No.: HY-10595