1. Metabolic Enzyme/Protease
  2. Glucokinase
  3. RO-28-1675

RO-28-1675 

Cat. No.: HY-10595 Purity: 99.95%
Handling Instructions

RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes.

For research use only. We do not sell to patients.

RO-28-1675 Chemical Structure

RO-28-1675 Chemical Structure

CAS No. : 300353-13-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 284 In-stock
Estimated Time of Arrival: December 31
5 mg USD 258 In-stock
Estimated Time of Arrival: December 31
10 mg USD 444 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes[1][2][3].

IC50 & Target

EC50: 54 nM (glucokinase)[1]

In Vitro

RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RO-28-1675 (50 mg/kg; p.o.) reduces blood glucose levels in wild-type C57BL/6J mice[2].
RO-28-1675 (10 mg/kg; p.o.) displays lower clearance and higher oral bioavailability[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10 weeks old male C57BL/6J mice[2]
Dosage: 50 mg/kg
Administration: Oral administration
Result: Reduced blood glucose levels.
Animal Model: C57BL/6J mice[3]
Dosage: 10 mg/kg
Administration: Oral administration
Result: AUC0-inf (5150 ng•h/mL), Cmax (1140 μg/mL) ,T max (3.3 hours ), Fpo (92.8%) with 10 mg/kg orally administered.
Molecular Weight

378.51

Formula

C₁₈H₂₂N₂O₃S₂

CAS No.

300353-13-3

SMILES

O=C([[email protected]@H](C1=CC=C(C=C1)S(=O)(C)=O)CC2CCCC2)NC3=NC=CS3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (132.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6419 mL 13.2097 mL 26.4194 mL
5 mM 0.5284 mL 2.6419 mL 5.2839 mL
10 mM 0.2642 mL 1.3210 mL 2.6419 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.60 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.60 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.60 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.95%

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Keywords:

RO-28-1675GlucokinaseHexokinase IVHexokinase Dglucokinasetype2diabetesregulatoryproteinGKdirectactivatorsGKAsInhibitorinhibitorinhibit

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Product Name:
RO-28-1675
Cat. No.:
HY-10595
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