1. Metabolic Enzyme/Protease
  2. Glucokinase
  3. AZD1656

AZD1656 

Cat. No.: HY-15675
Handling Instructions

AZD1656 is a potent, selective and orally active glucokinase activator with an EC50 of 60 nM. AZD1656 has the potential for type 2 diabetes research.

For research use only. We do not sell to patients.

AZD1656 Chemical Structure

AZD1656 Chemical Structure

CAS No. : 919783-22-5

Size Price Stock
5 mg USD 370 Ask For Quote & Lead Time
10 mg USD 600 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AZD1656 is a potent, selective and orally active glucokinase activator with an EC50 of 60 nM. AZD1656 has the potential for type 2 diabetes research[1][2][3].

IC50 & Target

EC50: 60 nM (Glucokinase)[2]

In Vivo

AZD1656 (0-9 mg/kg; oral gavage; daily; for 8 weeks; C57BL/6 mice) treatment shows lowered blood glucose and glucose excursion and raised insulin. Liver mRNA levels for various ChREBP target genes including carbohydrate response element binding protein beta isoform (ChREBP-β), G6pc, Pklr, Acly, Acac and Gpd2 are increased by AZD1656[1].

Animal Model: C57BL/6 mice[1]
Dosage: 0 mg/kg, 2 mg/kg, 4.5 mg/kg, 9 mg/kg
Administration: Oral gavage; daily; for 8 weeks
Result: Administered 2 hours before the oral glucose tolerance test, lowered blood glucose and glucose excursion and raised insulin.
Molecular Weight

478.50

Formula

C₂₄H₂₆N₆O₅

CAS No.

919783-22-5

SMILES

O=C(NC1=NC=C(C)N=C1)C2=CC(O[[email protected]@H](C)COC)=CC(OC3=NC=C(C(N4CCC4)=O)N=C3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AZD1656AZD 1656AZD-1656GlucokinaseHexokinase IVHexokinase DhypoglycemiaglucagonepinephrineChREBP-βG6pcG6PantihyperglycemicInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AZD1656
Cat. No.:
HY-15675
Quantity:
MCE Japan Authorized Agent: