2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glucokinase
  5. Glucokinase Activator

Glucokinase Activator

Glucokinase Activators (18):

Cat. No. Product Name Effect Purity
  • HY-N2341
    Palmitelaidic Acid
    		Activator ≥99.0%
    Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
  • HY-109030
    Dorzagliatin
    		Activator 99.87%
    Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes.
  • HY-10595
    RO-28-1675
    		Activator 99.95%
    RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes.
  • HY-19843
    MK-0941
    		Activator 99.28%
    MK-0941 is a potent, orally active and allosteric glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 has potential in the treatment of type 2 diabetes.
  • HY-13529
    Globalagliatin
    		Activator ≥98.0%
    Globalagliatin (LY2608204) is a activator of glucokinase (GK) with EC50 of 42 nM.
  • HY-15671
    GKA50
    		Activator 99.57%
    GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose). GKA50 stimulates insulin release from mouse islets of Langerhans. GKA50 is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca2+-dependent modulator of insulin secretion. GKA50 shows significant glucose lowering in high fat fed female rats.
  • HY-15675
    AZD1656
    		Activator 98.02%
    AZD1656 is a potent, selective and orally active glucokinase activator with an EC50 of 60 nM. AZD1656 has the potential for type 2 diabetes research.
  • HY-100221
    AM-2394
    		Activator 99.48%
    AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.
  • HY-133127
    AR453588
    		Activator 99.69%
    AR453588 is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM. AR453588 shows anti-hyperglycemic activity.
  • HY-100181
    PF-04991532
    		Activator ≥99.0%
    PF-04991532 is a potent, hepatoselective glucokinase activator with EC50s of 80 and 100 nM in human and rat, respectively.
  • HY-15671A
    GKA50 quarterhydrate
    		Activator ≥98.0%
    GKA50 quarterhydrate is a potent glucokinase activator (EC50=33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca2+-dependent modulator of insulin secretion. GKA50 quarterhydrate shows significant glucose lowering in high fat fed female rats.
  • HY-144287
    Glucokinase activator 3
    		Activator 98.36%
    Glucokinase activator 3 is a potent and full Glucokinase (GK) activator with an AC50 of 38 nM. Glucokinase activator 3 has the potential for the research of type 2 diabetes.
  • HY-144289
    BMS-820132
    		Activator 99.39%
    BMS-820132 is a partial glucokinase activator with a AC50 of 29 nM.
  • HY-133127A
    AR453588 hydrochloride
    		Activator
    AR453588 hydrochloride is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM. AR453588 hydrochloride shows anti-hyperglycemic activity.
  • HY-147254
    Cadisegliatin
    		Activator 99.10%
    Cadisegliatin (TTP-399) is a potential, orally active liver-selective glucokinase (GK) activator. Cadisegliatin has antihyperglycaemic activity. Cadisegliatin can be used for the research of type 2 diabetes.
  • HY-101788
    Glucokinase activator 1
    		Activator
    Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM.
  • HY-N2341S
    Palmitelaidic acid-d13
    		Activator
    Palmitelaidic acid-d13 is the deuterium labeled Palmitelaidic Acid. Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
  • HY-U00411
    PSN-GK1
    		Activator
    PSN-GK1 is a potent glucokinase activator with an EC50 of 0.13 μM.