Glucokinase Activator

Glucokinase activator 6 (compound 9) is a potent glucokinase activator, with an EC₅₀ of 0.09 μM. Glucokinase activator 6 can be used for type 2 diabetes (T2D) research.

LCZ960 is an orally active glucokinase (GK) activator. LCZ960 stimulates GK activity in hepatocytes in vitro and stimulates glucose uptake in vivo through hepatic GK activation. LCZ960 lowers blood glucose in mice with diet-induced obesity (DIO). LCZ960 maintains normoglycemia and improves glucose tolerance in DIO mice and rats. LCZ960 stimulates glycogen synthase flux and increases hepatic glycogen turnover in rats. LCZ960 induces increased hepatic glycogen recycling. LCZ960 can be used to study high-fat diet-induced obesity and type 2 diabetes.

NVP-LBX192 (Compound 17c) is a glucokinase activator with a K(a) of 39 nM. NVP-LBX192 can significantly reduce glucose levels. NVP-LBX192 can be used for the research of metabolic disease, such as type 2 diabetes.

AZD1092 is an orally active glucokinase (GK) activator with an EC₅₀ value of 0.03 μM. AZD1092 can be used for the research of Type 2 Diabetes (T2D).

Glucolipsin B is a glucokinase activator.

Glucokinase activator 7 is a Glucokinase activator. Glucokinase activator 7 can be used for research of diabetes, hyperglycemia and other diseases (Compound in Page 176 of Ref.).

Piragliatin (RO4389620) is an activator for glucokinase, which reduces endogenous glucose production, increases β-cell function and glucose utilization, and thus decreases the blood glucose levels. Piragliatin exhibits antidiabetic efficacy.

Nerigliatin (Standard) is the analytical standard of Nerigliatin. This product is intended for research and analytical applications. Nerigliatin (PF-04937319) is a orally active glucokinase activator (GKA) with EC50 value of 154.4 μM. Nerigliatin maintains glucose-lowering efficacy. Nerigliatin causes peripheral nerve degeneration. Nerigliatin can be used in type 2 diabetes research.

AM-2394 (Standard) is the analytical standard of AM-2394 (HY-100221). This product is intended for research and analytical applications. AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.

Glucokinase activator 10, a thiazole-based compound, is a liver-selective and orally active glucokinase activator with an EC₅₀ of 42 nM. Glucokinase activator 10 exhibits significant glucose lowering in acute diet-induced obese mouse oral glucose tolerance (OGTT) test. Glucokinase activator 10 can be used for the study of metabolic disorders.

Glucolipsin A is a glucokinase activator.

RO-28-1675 (Standard) is the analytical standard of RO-28-1675 (HY-10595). This product is intended for research and analytical applications. RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC₅₀ of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes.

(S,S)-Sinogliatin ((S,S)-HMS-5552) is the (S,S) -enantiomer of Sinogliatin. Sinogliatin is a glucokinase activator that can be used to study type 2 diabetes.

PF-04991532 (Standard) is the analytical standard of PF-04991532 (HY-100181). This product is intended for research and analytical applications. PF-04991532 is a potent, hepatoselective glucokinase activator with EC50s of 80 and 100 nM in human and rat, respectively.

Glucokinase activator 8 is an activator for glucokinase.

GKA-71 is an orally active Glucokinase activator, possesses an islet protective effect.

Glucokinase activator 11 is a substituted benzamide derivative and glucokinase activator. Glucokinase activator 11 can be used for the research of type ii diabetes.

Glucokinase activator 5 (compound 6) is a glucokinase activator.

PSN-GK1 is a potent glucokinase activator with an EC₅₀ of 0.13 μM.