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Cat. No.: HY-179419

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Glucokinase activator 10

Glucokinase activator 10, a thiazole-based compound, is a liver-selective and orally active glucokinase activator with an EC₅₀ of 42 nM. Glucokinase activator 10 exhibits significant glucose lowering in acute diet-induced obese mouse oral glucose tolerance (OGTT) test. Glucokinase activator 10 can be used for the study of metabolic disorders.

For research use only. We do not sell to patients.

Formula: C₂₅H₃₂N₃O₈PS₂
Molecular Weight:597.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Glucokinase activator 10 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vivo

Glucokinase activator 10 (compound 13) (3 μmol/kg (179.3 μg/kg); p.o.; once) demonstrates significant glucose lowering in acute diet-induced obese (DIO) mouse OGTT studies. However, insulin secretion is observed at 100 mmol/kg (even without administration of an OGTT)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

An acute diet-induced obese (DIO) mouse OGTT test^[1]
Dosage:

3 μmol/kg (179.3 μg/kg)
Administration:

p.o.; once
Result:

Demonstrated significant glucose lowering.

Chemical Information

Molecular Weight 597.64
Formula C₂₅H₃₂N₃O₈PS₂
SMILES

O=S(C1=CC=C(OC2=CC(C(NC3=NC(CCCOP(C)(C)=O)=CS3)=O)=CC(O[C@@H](C)COC)=C2)C=N1)(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yoon DS, et al. Discovery of liver-selective glucokinase activators comprising N-(4-alkylthiazol-2-yl)benzamides and N-(3-alkyl-1,2,4-thiadiazol-5-yl)benzamides for the treatment of metabolic disorders. Bioorg Med Chem Lett. 2025 Jul 1;122:130192. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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