1191996-10-7
1191996-10-7
Chemical Structure
(S,S)-Sinogliatin
Synonym(s): (S,S)-HMS-5552; (S,S)-RO-5305552
- CAS No.: 1191996-10-7
- Formula:C22H27ClN4O5
- Molecular Weight:462.93
IUPAC Name: (S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide
InChIKey: HMUMWSORCUWQJO-YJBOKZPZSA-N
SMILES: CC(C[C@@H](C(NC1=NN(C=C1)C[C@@H](CO)O)=O)N2CC(OC3=CC=CC=C3Cl)=CC2=O)C
Biological Activity: (S,S)-Sinogliatin ((S,S)-HMS-5552) is the (S,S) -enantiomer of Sinogliatin. Sinogliatin is a glucokinase activator that can be used to study type 2 diabetes[1].
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(S,S)-Sinogliatin | (S,S)-Sinogliatin ((S,S)-HMS-5552) is the (S,S) -enantiomer of Sinogliatin. Sinogliatin is a glucokinase activator that can be used to study type 2 diabetes. | |||||||||||||||||||||
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References
- [1]. Song L, et al. Development of a Physiologically Based Pharmacokinetic Model for Sinogliatin, a First-in-Class Glucokinase Activator, by Integrating Allometric Scaling, In Vitro to In Vivo Exploration and Steady-State Concentration-Mean Residence Time Methods: Mechanistic Understanding of its Pharmacokinetics. Clin Pharmacokinet. 2018 Oct;57(10):1307-1323. [Content Brief]
