1. Metabolic Enzyme/Protease
  2. Glucokinase
  3. AM-2394

AM-2394 

Cat. No.: HY-100221 Purity: 98.71%
Handling Instructions

AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.

For research use only. We do not sell to patients.

AM-2394 Chemical Structure

AM-2394 Chemical Structure

CAS No. : 1442684-77-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
5 mg USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 192 In-stock
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.

IC50 & Target

EC50: 60 nM (glucokinase)[1]

In Vivo

AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (70.84 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3614 mL 11.8072 mL 23.6144 mL
5 mM 0.4723 mL 2.3614 mL 4.7229 mL
10 mM 0.2361 mL 1.1807 mL 2.3614 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice[1]
In order to determine the effect of AM-2394 in an animal model of type 2 diabetes, it was administered per os (PO) to male ob/ob mice 30 minutes prior to performing an oral glucose tolerance test (OGTT). Doses of 1, 3, 10, 30 mg/kg each reduced glucose excursion, with maximal efficacy seen at 3 mg/kg.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

423.47

Formula

C₂₂H₂₅N₅O₄

CAS No.

1442684-77-6

SMILES

O=C(NC)NC1=CC(OC2=CC(C)=CN=C2)=C(C3=CC=C(OCC(C)(O)C)N=C3)C=N1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
AM-2394
Cat. No.:
HY-100221
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AM-2394

Cat. No.: HY-100221