2. Metabolic Enzyme/Protease
  3. Glucokinase
  4. AZD1092

AZD1092 is an orally active glucokinase (GK) activator with an EC50 value of 0.03 μM. AZD1092 can be used for the research of Type 2 Diabetes (T2D).

For research use only. We do not sell to patients.

AZD1092 Chemical Structure

AZD1092 Chemical Structure

CAS No. : 871656-65-4

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AZD1092 Related Antibodies

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Description

AZD1092 is an orally active glucokinase (GK) activator with an EC50 value of 0.03 μM. AZD1092 can be used for the research of Type 2 Diabetes (T2D)[1].

IC50 & Target

EC50: 0.03 μM (glucokinase)[1]
In Vitro

AZD1092 has activity for glucokinase with an EC50 value of 0.03 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AZD1092 Related Antibodies
In Vivo

AZD1092 (oral; 1, 3, 10 mg/kg) exhibits dose dependent reduction of glucose excursion and has glucose lowering efficacy in Zucker rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Zucker rats[1]
Dosage: 1, 3, 10 mg/kg
Administration: Oral
Result: Exhibited dose dependent reduction of glucose excursion in oral glucose tolerance tests in high fat fed female Zucker rats and glucose lowering efficacy in free feeding glucose profiles in male Zucker rats.
Molecular Weight

450.49

Formula

C24H26N4O5
CAS No.
SMILES

O=C(C1=CC(O[C@H](CO)C)=CC(OC2=CC=C(C=C2)C(N3CCC3)=O)=C1)NC4=NN(C=C4)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AZD1092 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD1092871656-65-4AZD 1092AZD-1092GlucokinaseHexokinase IVHexokinase DType 2 Diabetes (T2D)glucokinaseglycaemic controlInhibitorinhibitorinhibit

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