Glucokinase activator 1
Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM.
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- CAS No.: 1328987-85-4
- 화학식: C27H20F2N2O7S2
- 분자량:586.58
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
EC50: 34 nM (Glucokinase)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6J mice (age 8-10 weeks; 25±5 g)[1]
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Dosage:1 or 3 mg/kg (i.v.), 30 mg/kg (oral)
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Administration:I.v. or oral
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Result:Showed an excellent PK profile and exhibited 35- and 68- fold higher liver concentrations at 1 and 3 h time point, respectively, compared with plasma[1].
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Animal Model:Male C57BL/6J mice of 10-12 weeks[1]
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Dosage:3 to 300 mg/kg
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Administration:Oral (15, 30, 60, 120 and 180 minutes)
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Result:Demonstrated 21% and 34% significant AUC glucose reduction at oral dose of 30 and 100 mg/kg, respectively[1].
Chemical Information
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CAS No. 1328987-85-4
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분자량 586.58
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화학식 C27H20F2N2O7S2
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SMILES
O=S(C1=CC=C([C@H](C(NC2=NC=C(OC3=CC=C(C(O)=O)C=C3)S2)=O)OC4=CC=C(F)C=C4F)C=C1)(C5CC5)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glucokinase activator 1 Related Classifications
HY-101788 Related Classifications
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