1. Metabolic Enzyme/Protease
  2. Glucokinase
  3. MK-0941 free base

MK-0941 free base 

Cat. No.: HY-19843A
Handling Instructions

MK-0941 free base is an orally active glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.

For research use only. We do not sell to patients.

MK-0941 free base Chemical Structure

MK-0941 free base Chemical Structure

CAS No. : 752240-01-0

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Description

MK-0941 free base is an orally active glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes[1][2].

IC50 & Target

Glucokinase[1][2].

In Vivo

MK-0941 free base (3 or 10 mg/kg, sing oral dose) treatment reduced blood glucose significantly in db/db diabetic mouse[1].

Animal Model: Male db/db and db/+ (lean) mice (9-10 weeks of age, weighing 43-45 g) [1].
Dosage: 3 or 10 mg/kg.
Administration: Oral gavage, single dose.
Result: Resulted in significant reduction in blood glucose. These two doses lowered blood glucose similarly at 1 h after dosing, suggesting that saturation of effect was approached.
Molecular Weight

460.50

Formula

C₂₁H₂₄N₄O₆S

CAS No.

752240-01-0

SMILES

O=C(NC1=NN(C)C=C1)C2=CC(O[[email protected]@H](C)CO)=CC(OC3=CC=C(S(=O)(CC)=O)N=C3)=C2

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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MK-0941 free base
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HY-19843A
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