SHP2 ATTEC degrader-1
SHP2 ATTEC degrader-1 is a SHP2 ATTEC degrader. SHP2 ATTEC degrader-1 has degradation rate of 83.31 at 1.0 μM for 24 h in the PANC-1 cell line. SHP2 ATTEC degrader-1 inhibits cell growth in vivo and in vitro. SHP2 ATTEC degrader-1 induces apoptosis and increases the expression of the epithelial marker ( E-cadherin)， and reduces the expression of interstitial markers (such as N-cadherin, Vimentin) (Pink: LC3 ligand (HY-174085); Black :linker HY-140468; Blue: SHP2 ligand (HY-174084).
For research use only. We do not sell to patients.
- Formula: C43H51N7O10S
- Molecular Weight:857.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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Molecular Weight 857.97
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Formula C43H51N7O10S
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SMILES
NC1=C(N=CC(N2CCC(C)(CC2)NC(CCOCCOCCOCCNC(CCC(NC3=CC=C(C=C3)C4=CC(OC5=C4C(O)=CC(O)=C5)=O)=O)=O)=O)=N1)C6=CSC=C6C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SHP2 ATTEC degrader-1 Related Classifications
HY-173560 Related Classifications
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