DS-PPE-GW
DS-PPE-GW is a BCR-ABL ATTEC degrader. DS-PPE-GW connects BCR-ABL and LC3B, thereby tethering BCR-ABL to the autophagosome membrane. DS-PPE-GW shows potent BCR-ABL degradation. DS-PPE-GW has anticancer activity against chronic myeloid leukemia (Pink: LC3B ligand (HY-10542); Blue: BCR-ABL ligand (HY-107447); Black: Linker (HY-W001860)).
For research use only. We do not sell to patients.
- Formula: C44H41Br2ClIN9O5S
- Molecular Weight:1130.08
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Chemical Information
-
Molecular Weight 1130.08
-
Formula C44H41Br2ClIN9O5S
-
SMILES
BrC1=CC(/C=C(C2=C(N3)C=CC(I)=C2)\C3=O)=CC(Br)=C1OCC(N4CCC(CC(N5CCN(C6=CC(NC7=NC=C(C(NC8=C(Cl)C=CC=C8C)=O)S7)=NC(C)=N6)CC5)=O)CC4)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)