2. Autophagy PROTAC Protein Tyrosine Kinase/RTK
  3. ATTECs Bcr-Abl Autophagy
  4. DS-PPE-GW

DS-PPE-GW is a BCR-ABL ATTEC degrader. DS-PPE-GW connects BCR-ABL and LC3B, thereby tethering BCR-ABL to the autophagosome membrane. DS-PPE-GW shows potent BCR-ABL degradation. DS-PPE-GW has anticancer activity against chronic myeloid leukemia (Pink: LC3B ligand (HY-10542); Blue: BCR-ABL ligand (HY-107447); Black: Linker (HY-W001860)).

For research use only. We do not sell to patients.

DS-PPE-GW

DS-PPE-GW Chemical Structure

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DS-PPE-GW Related Antibodies

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Description

DS-PPE-GW is a BCR-ABL ATTEC degrader. DS-PPE-GW connects BCR-ABL and LC3B, thereby tethering BCR-ABL to the autophagosome membrane. DS-PPE-GW shows potent BCR-ABL degradation. DS-PPE-GW has anticancer activity against chronic myeloid leukemia (Pink: LC3B ligand (HY-10542); Blue: BCR-ABL ligand (HY-107447); Black: Linker (HY-W001860))[1].

Molecular Weight

1130.08

Formula

C44H41Br2ClIN9O5S
SMILES

BrC1=CC(/C=C(C2=C(N3)C=CC(I)=C2)\C3=O)=CC(Br)=C1OCC(N4CCC(CC(N5CCN(C6=CC(NC7=NC=C(C(NC8=C(Cl)C=CC=C8C)=O)S7)=NC(C)=N6)CC5)=O)CC4)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DS-PPE-GW Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS-PPE-GWATTECsBcr-AblAutophagyAutophagosome-tethering compoundsInhibitorinhibitorinhibit

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