NAMPT degrader-1
NAMPT degrader-1 (Compound A3), an autophagosome-tethering compound (ATTEC), is an nicotinamide phosphoribosyltransferase (NAMPT) degrader with an IC50 of 0.023 μM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the autophagy-lysosomal pathway and shows excellent cellular antitumor potency.
For research use only. We do not sell to patients.
- CAS No.: 3011778-39-2
- Formula: C56H68ClN9O5S2
- Molecular Weight:1046.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.023 μM (NAMPT)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
0.046 μM
Compound: A3
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Antiproliferative activity against human A2780 cells overexpressing NAMPT assessed as cell growth inhibition incubated for 72 hrs
Antiproliferative activity against human A2780 cells overexpressing NAMPT assessed as cell growth inhibition incubated for 72 hrs
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[PMID: 35588495] |
Chemical Information
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CAS No. 3011778-39-2
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Molecular Weight 1046.78
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Formula C56H68ClN9O5S2
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SMILES
O=C1N(C([C@@H](C(C)C)N(CCCNC(CCCCCCCCN2CCN(S(C3=CC=C(NC(NCC4=CC=CN=C4)=S)C=C3)(=O)=O)CC2)=O)C(C5=CC=C(C=C5)C)=O)=NC6=CC(Cl)=CC=C61)CC7=CC=CC=C7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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