NAMPT degrader-1
NAMPT degrader-1 (Compound A3), an autophagosome-tethering compound (ATTEC), is an nicotinamide phosphoribosyltransferase (NAMPT) degrader with an IC50 of 0.023 μM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the autophagy-lysosomal pathway and shows excellent cellular antitumor potency.
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- No. CAS: 3011778-39-2
- Fòrmula: C56H68ClN9O5S2
- Peso molecular:1046.78
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
IC50: 0.023 μM (NAMPT)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
0.046 μM
Compound: A3
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Antiproliferative activity against human A2780 cells overexpressing NAMPT assessed as cell growth inhibition incubated for 72 hrs
Antiproliferative activity against human A2780 cells overexpressing NAMPT assessed as cell growth inhibition incubated for 72 hrs
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[PMID: 35588495] |
Chemical Information
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No. CAS 3011778-39-2
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Peso molecular 1046.78
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Fòrmula C56H68ClN9O5S2
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SMILES
O=C1N(C([C@@H](C(C)C)N(CCCNC(CCCCCCCCN2CCN(S(C3=CC=C(NC(NCC4=CC=CN=C4)=S)C=C3)(=O)=O)CC2)=O)C(C5=CC=C(C=C5)C)=O)=NC6=CC(Cl)=CC=C61)CC7=CC=CC=C7
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NAMPT degrader-1 Related Classifications
HY-147656 Related Classifications
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