2. PROTAC Metabolic Enzyme/Protease Autophagy
  3. ATTECs NAMPT Autophagy
  4. NAMPT degrader-1

NAMPT degrader-1 (Compound A3), an autophagosome-tethering compound (ATTEC), is an nicotinamide phosphoribosyltransferase (NAMPT) degrader with an IC50 of 0.023 μM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the autophagy-lysosomal pathway and shows excellent cellular antitumor potency.

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NAMPT degrader-1

NAMPT degrader-1 Chemical Structure

CAS No. : 3011778-39-2

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NAMPT degrader-1 Related Antibodies

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Description

NAMPT degrader-1 (Compound A3), an autophagosome-tethering compound (ATTEC), is an nicotinamide phosphoribosyltransferase (NAMPT) degrader with an IC50 of 0.023 μM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the autophagy-lysosomal pathway and shows excellent cellular antitumor potency[1].

IC50 & Target

IC50: 0.023 μM (NAMPT)[1]
Cellular Effect
Cell Line Type Value Description References
A2780 IC50
0.046 μM
Compound: A3
Antiproliferative activity against human A2780 cells overexpressing NAMPT assessed as cell growth inhibition incubated for 72 hrs
Antiproliferative activity against human A2780 cells overexpressing NAMPT assessed as cell growth inhibition incubated for 72 hrs
[PMID: 35588495]
Molecular Weight

1046.78

Formula

C56H68ClN9O5S2
CAS No.
SMILES

O=C1N(C([C@@H](C(C)C)N(CCCNC(CCCCCCCCN2CCN(S(C3=CC=C(NC(NCC4=CC=CN=C4)=S)C=C3)(=O)=O)CC2)=O)C(C5=CC=C(C=C5)C)=O)=NC6=CC(Cl)=CC=C61)CC7=CC=CC=C7
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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NAMPT degrader-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAMPT degrader-13011778-39-2NAMPT degrader1NAMPT degrader 1ATTECsNAMPTAutophagyAutophagosome-tethering compoundsNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorA2780antitumorautophagydegradationInhibitorinhibitorinhibit

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