2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NLRP3-IN-20

NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis.

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NLRP3-IN-20 Chemical Structure

NLRP3-IN-20 Chemical Structure

CAS No. : 2428478-22-0

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NLRP3-IN-20 Related Antibodies

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Description

NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis[1].

IC50 & Target

NLRP3[1]
In Vivo


Pharmacokinetic Analysis in Mouse[1]

Route Dose (mg/kg) T1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-inf (ng·h/mL) MRT0-inf (h) Vz (mL/kg) Cl (mL/h/kg) F (%)
i.v. 5 4.01 0.083 22567 130240/ 5.30 226 38.8
p.o. 10 3.50 0.667 33867 221955 4.79 / / 85.21

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

413.53

Formula

C22H27N3O3S
CAS No.
SMILES

O=S(C1=CC=C(CN(C)C)C=C1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NLRP3-IN-20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-202428478-22-0NOD-like Receptor (NLR)Inhibitorinhibitorinhibit

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