NLRP3-IN-20
NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis.
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- CAS No.: 2428478-22-0
- Formule: C22H27N3O3S
- Masse moléculaire:413.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
NLRP3[1]
Pharmacokinetic Analysis in Mouse[1]
| Route | Dose (mg/kg) | T1/2 (h) | Tmax (h) | Cmax (ng/mL) | AUC0-inf (ng·h/mL) | MRT0-inf (h) | Vz (mL/kg) | Cl (mL/h/kg) | F (%) |
| i.v. | 5 | 4.01 | 0.083 | 22567 | 130240/ | 5.30 | 226 | 38.8 | |
| p.o. | 10 | 3.50 | 0.667 | 33867 | 221955 | 4.79 | / | / | 85.21 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2428478-22-0
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Masse moléculaire 413.53
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Formule C22H27N3O3S
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SMILES
O=S(C1=CC=C(CN(C)C)C=C1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NLRP3-IN-20 Related Classifications
HY-156121 Related Classifications
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