1621175-65-2
1621175-65-2
Chemical Structure
TC-G-1008
Synonym(s): GPR39-C3
- CAS No.: 1621175-65-2
- Formula:C18H19ClN6O2S
- Molecular Weight:418.90
IUPAC Name: N-(3-chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide
InChIKey: DRSZMILOMUPIBJ-UHFFFAOYSA-N
SMILES: CS(=O)(NC1=CC=C(CNC2=NC(NC)=NC(C3=NC=CC=C3)=C2)C(Cl)=C1)=O
Biological Activity: TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TC-G-1008 | 99.36% | TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively. | ||||||||||||||||||||
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TC-G-1008 (Standard) | ≥98% | TC-G-1008 (Standard) is the analytical standard of TC-G-1008 (HY-103007). This product is intended for research and analytical applications. TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively. | ||||||||||||||||||||
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Vismodegib (Standard) | ≥98% | Vismodegib (Standard) is the analytical standard of Vismodegib. This product is intended for research and analytical applications. Vismodegib (GDC-0449) is a BBB-permeable and orally active hedgehog pathway inhibitor with an IC50 of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively. | ||||||||||||||||||||
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CGP60474 | 98.90% | CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively). CGP60474 is a selective and ATP-competitive PKC inhibitor. | ||||||||||||||||||||
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WN1316 | WN1316 is an oral active antioxidant agent. WN1316 shows neuroprotectant activity and can be used for study of amyotrophic lateral sclerosis. | |||||||||||||||||||||
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RDR03871 | 98.00% | RDR03871 (compound 2) is a potent dual MDM2/MDM4 inhibitor with IC50 values of 35.4 nM and 10.4 nM for MDM2-p53 and MDM4-p53, respectively. | ||||||||||||||||||||
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Hepcidin antagonist-1 | 98.07% | Hepcidin antagonist-1 (example 104) is a potent hepcidin (hepcidine) antagonist with an IC50<50 μM. Hepcidin antagonist-1 can be used for researching iron metabolism disorders, such as anemias. | ||||||||||||||||||||
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Anticancer agent 71 | Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity. | |||||||||||||||||||||
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DHX9-IN-12 | DHX9-IN-12 (83) is a RNA helicase DHX9 inhibitor, with an EC50 of 0.917 μM in DHX9 cellular target engagement. Used in cancer research. | |||||||||||||||||||||
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DHX9-IN-14 | DHX9-IN-14 (161) is a RNA helicase DHX9 inhibitor, with an EC50 of 3.4 μM in DHX9 cellular target engagement. Used in cancer research. | |||||||||||||||||||||
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AS2690168 hydrochloride | AS2690168 hydrochloride is an orally active RANKL signal transduction inhibitor which suppresses RANKL-induced osteoclastogenesis of RAW264 cells. AS2690168 can be utilized in research related to pathological osteolysis. | |||||||||||||||||||||
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Defactinib analogue-1 | 99.35% | Defactinib analogue-1 (Compound 7) is a ligand for target protein Fak, that can be used for synthesis of PROTAC FAK degrader 1 (HY-119932). | ||||||||||||||||||||
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