Hyaluronidase (human recombinant)
Based on 19 publication(s) in Google Scholar
Hyaluronidase (human recombinant) (Vorhyaluronidase alfa; rHuPH 20) is an enzyme that catalyzes the degradation of hyaluronic acid. Hyaluronidase (human recombinant) is used to improve the absorption and dispersal of parenteral fluids, medications, and contrast media.
For research use only. We do not sell to patients.
- CAS No.: 37326-33-3
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Hyaluronidase (human recombinant)
More- Mol Cancer. 2024 Jan 10;23(1):12. [Abstract]
- Adv Mater. 2025 Nov 28:e18378. [Abstract]
- Cancer Res. 2025 Aug 1;85(15):2805-2819. [Abstract]
- Nat Commun. 2023 May 26;14(1):3050. [Abstract]
- Theranostics. 2023 Mar 27;13(6):2040-2056. [Abstract]
- Adv Sci (Weinh). 2025 Apr 3:e2412356. [Abstract]
- J Control Release. 2026 Jun 10:394:114858. [Abstract]
- Cell Death Dis. 2025 Mar 20;16(1):190. [Abstract]
- Mater Today Bio. 2026 Mar 31:38:103086. [Abstract]
- Cell Biosci. 2023 Aug 10;13(1):147. [Abstract]
- J Mol Cell Biol. 2026 Jun 25:mjag019. [Abstract]
- Int J Mol Sci. 2025 Nov 27;26(23):11475. [Abstract]
- Cell Oncol (Dordr). 2024 Dec;47(6):2439-2460. [Abstract]
- Reproduction. 2026 Jan 15;171(1):xaaf013. [Abstract]
- Animals (Basel). 2025 Nov 16;15(22):3304. [Abstract]
- Oral Dis. 2026 Apr 15. [Abstract]
- Drug Dev Ind Pharm. 2023 Feb;49(2):189-206. [Abstract]
- Vet Med Int. 2026 May 21:2026:6119294. [Abstract]
- Preprints. 2025 Nov 26.
Customer Validation & Images
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IHC
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In Vivo Efficacy Study
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In Vivo Efficacy Study
Biological Activity
Hyaluronidase (human recombinant) improves intracytoplasmic sperm injection survival and fertilization rates[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 37326-33-3
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Hyaluronidase (human recombinant)]
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Synonyms
Vorhyaluronidase alfa; rHuPH 20
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (19)
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Journal Impact Factor
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Most Recent
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Mol Cancer
Organoids derived from patients provide a new opportunity for research and individualized treatment of malignant peritoneal mesothelioma. [Abstract]2024 Jan 10;23(1):12. PMID: 38200517 -
Adv Mater
Disrupting Complement-Inflammation Positive Feedback Circuit via Oligonucleotide Hydrogel Microspheres for Reversing Joint Inflammation. [Abstract]2025 Nov 28:e18378. PMID: 41312643 -
Cancer Res
Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor-Stroma Ratio and Promote Cancer Progression. [Abstract]2025 Aug 1;85(15):2805-2819. PMID: 40623046
Hyaluronidase (human recombinant) purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Aug 1;85(15):2805-2819. [Abstract]
B, Growth curves of PDX mice treated with PBS, everolimus, PEGPH20 (Hyaluronidase), and everolimus combined with PEGPH20 (n = 5 per group). C, H&E staining and IHC were used to demonstrate the effects of different drug administration strategies on tumor stroma and CD31+ cell and αSMA+ cell number
Hyaluronidase (human recombinant) purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Aug 1;85(15):2805-2819. [Abstract]
E and F, Flow cytometry analysis was used to demonstrate the effects of different drug administration strategies on the proportion of TipECs. Hyaluronidase (PEGPH20)
Hyaluronidase (human recombinant) purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Aug 1;85(15):2805-2819. [Abstract]
The effects of different drug administration strategies in the BON1+ HUVEC (4:1) model. Hyaluronidase (PEGPH20)
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Nat Commun
TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation. [Abstract]2023 May 26;14(1):3050. PMID: 37237031 -
Theranostics
Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages. [Abstract]2023 Mar 27;13(6):2040-2056. PMID: 37064877 -
Adv Sci (Weinh)
Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases. [Abstract]2025 Apr 3:e2412356. PMID: 40178289 -
J Control Release
Hydrogel-immobilized coacervate droplets enable microenvironment-responsive sustained drug release to accelerate diabetic foot ulcers healing. [Abstract]2026 Jun 10:394:114858. PMID: 41881075 -
Cell Death Dis
The role of vitamin K and its antagonist in the process of ferroptosis-damaged RPE-mediated CNV. [Abstract]2025 Mar 20;16(1):190. PMID: 40108164 -
Mater Today Bio
Mannosylated graphene oxide nanotherapeutics co-delivering docetaxel and a STING agonist reprogram myeloid cells and potentiate antitumor immunity. [Abstract]2026 Mar 31:38:103086. PMID: 42006712 -
Cell Biosci
Tumor-derived interleukin-1 receptor antagonist exhibits immunosuppressive functions and promotes pancreatic cancer. [Abstract]2023 Aug 10;13(1):147. PMID: 37563620 -
J Mol Cell Biol
Microtubule-associated CCDC112 is essential for spermiogenesis and male fertility in mice. [Abstract]2026 Jun 25:mjag019. PMID: 42348320 -
Int J Mol Sci
Melatonin Rescues Heat Stress-Induced Suppression of TCA Cycle and Mitochondrial Damage in Goat Sertoli Cells. [Abstract]2025 Nov 27;26(23):11475. PMID: 41373630 -
Cell Oncol (Dordr)
GALNT6 drives lenvatinib resistance in hepatocellular carcinoma through autophagy and cancer-associated fibroblast activation. [Abstract]2024 Dec;47(6):2439-2460. PMID: 39718738 -
Reproduction
2026 Jan 15;171(1):xaaf013. PMID: 41575147 -
Animals (Basel)
Optimization of Hydrogen Peroxide Concentrations for Inducing Oxidative Stress in Bovine Oocytes Prior to In Vitro Maturation. [Abstract]2025 Nov 16;15(22):3304. PMID: 41302012 -
Oral Dis
2026 Apr 15. PMID: 41986910 -
Drug Dev Ind Pharm
Multiple stimulus-response berberine plus baicalin micelles with particle size-charge-release triple variable properties for breast cancer therapy. [Abstract]2023 Feb;49(2):189-206. PMID: 36971392 -
Vet Med Int
Sericin Supplementation Prior to and During In Vitro Maturation Mitigates H2O2-Induced Oxidative Stress in Bovine Oocytes. [Abstract]2026 May 21:2026:6119294. PMID: 42180161 -
Purity & Documentation
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Data Sheet (268 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. E J Menzel, et al. Hyaluronidase and its substrate hyaluronan: biochemistry, biological activities and therapeutic uses. Cancer Lett. 1998 Sep 11;131(1):3-11. [Content Brief]
[2]. Evison M, et al. Human recombinant hyaluronidase (Cumulase) improves intracytoplasmic sperm injection survival and fertilization rates. Reprod Biomed Online. 2009 Jun;18(6):811-4. [Content Brief]
[3]. Gao X, et al. Mechanistic Modeling of the Effect of Recombinant Human Hyaluronidase (rHuPH20) on Subcutaneous Delivery of Cetuximab in Rats. Pharm Res. 2022 Aug;39(8):1867-1880. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hyaluronidase (human recombinant) Related Classifications
HY-108903 Related Classifications
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