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  3. Hyaluronidase (human recombinant)

Hyaluronidase (human recombinant)  (Synonyms: Vorhyaluronidase alfa; rHuPH 20)

Cat. No.: HY-108903
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Hyaluronidase (human recombinant) (Vorhyaluronidase alfa; rHuPH 20) is an enzyme that catalyzes the degradation of hyaluronic acid. Hyaluronidase (human recombinant) is used to improve the absorption and dispersal of parenteral fluids, medications, and contrast media.

For research use only. We do not sell to patients.

CAS No. : 37326-33-3

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150 U In-stock

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This product is a controlled substance and not for sale in your territory.

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Based on 16 publication(s) in Google Scholar

Other Forms of Hyaluronidase (human recombinant):

Top Publications Citing Use of Products

    Hyaluronidase (human recombinant) purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Aug 1;85(15):2805-2819.  [Abstract]

    B, Growth curves of PDX mice treated with PBS, everolimus, PEGPH20 (Hyaluronidase), and everolimus combined with PEGPH20 (n = 5 per group). C, H&E staining and IHC were used to demonstrate the effects of different drug administration strategies on tumor stroma and CD31+ cell and αSMA+ cell number

    Hyaluronidase (human recombinant) purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Aug 1;85(15):2805-2819.  [Abstract]

    E and F, Flow cytometry analysis was used to demonstrate the effects of different drug administration strategies on the proportion of TipECs. Hyaluronidase (PEGPH20)

    Hyaluronidase (human recombinant) purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Aug 1;85(15):2805-2819.  [Abstract]

    The effects of different drug administration strategies in the BON1+ HUVEC (4:1) model. Hyaluronidase (PEGPH20)
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    Description

    Hyaluronidase (human recombinant) (Vorhyaluronidase alfa; rHuPH 20) is an enzyme that catalyzes the degradation of hyaluronic acid. Hyaluronidase (human recombinant) is used to improve the absorption and dispersal of parenteral fluids, medications, and contrast media[1].

    In Vitro

    Hyaluronidase (human recombinant) improves intracytoplasmic sperm injection survival and fertilization rates[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Hyaluronidase (human recombinant) (rHuPH20, 2000 U/mL, volume ranged from 1.25 to 1.5 mL, s.c., pre-injection of 12 h or co-injection) results in a faster absorption of Cetuximab (HY-P9905) in rats[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Hyaluronidase (human recombinant)]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation

    References
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Hyaluronidase (human recombinant)
    Cat. No.:
    HY-108903
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