Hyaluronidase, Ovine testes
Based on 15 publication(s) in Google Scholar
Hyaluronidase, Ovine testes is an endoglycosidase. Hyaluronidase, Ovine testes specifically degrades Hyaluronic acid (HY-B0633A) and Chondroitin sulfate (HY-B2162) by hydrolyzing β-glycosidic bonds in acidic mucopolysaccharides. Hyaluronidase, Ovine testes disperses follicular cells during fertilization by breaking down the hyaluronic acid-rich cumulus. Hyaluronidase, Ovine testes can be used in the study of fertility-related diseases.
For research use only. We do not sell to patients.
- Purity: 95.00%
- CAS No.: 37326-33-3
- Molecular Weight:55000 (average)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Hyaluronidase, Ovine testes
More- Mol Cancer. 2024 Jan 10;23(1):12. [Abstract]
- Cancer Res. 2025 Aug 1;85(15):2805-2819. [Abstract]
- Nat Commun. 2023 May 26;14(1):3050. [Abstract]
- Theranostics. 2023 Mar 27;13(6):2040-2056. [Abstract]
- Adv Sci (Weinh). 2025 May;12(20):e2412356. [Abstract]
- J Control Release. 2026 Jun 10:394:114858. [Abstract]
- Mater Today Bio. 2026 Mar 31:38:103086. [Abstract]
- Cell Biosci. 2023 Aug 10;13(1):147. [Abstract]
- J Mol Cell Biol. 2026 Jun 25:mjag019. [Abstract]
- Int J Mol Sci. 2025 Nov 27;26(23):11475. [Abstract]
- Cell Oncol (Dordr). 2024 Dec;47(6):2439-2460. [Abstract]
- Reproduction. 2026 Jan 15;171(1):xaaf013. [Abstract]
- Oral Dis. 2026 Apr 15. [Abstract]
- Drug Dev Ind Pharm. 2023 Feb;49(2):189-206. [Abstract]
- Vet Med Int. 2026 May 21:2026:6119294. [Abstract]
Customer Validation & Images
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IHC
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In Vivo Efficacy Study
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In Vivo Efficacy Study
Biological Activity
Hyaluronidase inhibition test
Mix 10 μL of 8 mg/mL Hyaluronidase with the sample in a buffer solution (0.1 M acetate buffer, pH 3.6) and add it to a test tube. Incubate at 37 °C for 20 minutes.
(2) Add 20 μL of 12.5 mM calcium chloride to the mixture and incubate for another 20 minutes at 37°C.
(3) The activated Ca2+ mixture was treated with 50 μL of 2.4 μg/mL hyaluronic acid in the buffer and further incubated at 37°C for 40 minutes.
(4) Add 2 μL of 0.4 N sodium hydroxide and 20 μL of 0.4 N potassium tetraborate tetrahydrate, and then incubate in a water bath at 100°C for 3 minutes.
After cooling to room temperature, add 600 μL of DMAB solution to the mixture and incubate at 37°C for 20 minutes.
(6) Measure the absorbance at 585 nm using an microplate reader.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
3.2.1.35
≥400 U/mg protein
One unit is defined as the amount of enzyme that can cause a change in A600 of 0.330 per minute at pH 5.35, 37°C in a 2.0 mL reaction mixture (45 min assay).
Chemical Information
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CAS No. 37326-33-3
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Appearance Solid
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Molecular Weight 55000 (average)
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Color Off-white to yellow
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SMILES
[Hyaluronidase, Ovine testes]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (15)
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Journal Impact Factor
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Most Recent
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Mol Cancer
Organoids derived from patients provide a new opportunity for research and individualized treatment of malignant peritoneal mesothelioma. [Abstract]2024 Jan 10;23(1):12. PMID: 38200517 -
Cancer Res
Pancreatic Neuroendocrine Tumors Secrete Apolipoprotein E to Induce Tip Endothelial Cells That Remodel the Tumor-Stroma Ratio and Promote Cancer Progression. [Abstract]2025 Aug 1;85(15):2805-2819. PMID: 40623046
Hyaluronidase, Ovine testes purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Aug 1;85(15):2805-2819. [Abstract]
B, Growth curves of PDX mice treated with PBS, everolimus, PEGPH20 (Hyaluronidase), and everolimus combined with PEGPH20 (n = 5 per group). C, H&E staining and IHC were used to demonstrate the effects of different drug administration strategies on tumor stroma and CD31+ cell and αSMA+ cell number
Hyaluronidase, Ovine testes purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Aug 1;85(15):2805-2819. [Abstract]
E and F, Flow cytometry analysis was used to demonstrate the effects of different drug administration strategies on the proportion of TipECs. Hyaluronidase (PEGPH20)
Hyaluronidase, Ovine testes purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Aug 1;85(15):2805-2819. [Abstract]
The effects of different drug administration strategies in the BON1+ HUVEC (4:1) model. Hyaluronidase (PEGPH20)
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Nat Commun
TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation. [Abstract]2023 May 26;14(1):3050. PMID: 37237031 -
Theranostics
Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages. [Abstract]2023 Mar 27;13(6):2040-2056. PMID: 37064877 -
Adv Sci (Weinh)
Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases. [Abstract]2025 May;12(20):e2412356. PMID: 40178289 -
J Control Release
Hydrogel-immobilized coacervate droplets enable microenvironment-responsive sustained drug release to accelerate diabetic foot ulcers healing. [Abstract]2026 Jun 10:394:114858. PMID: 41881075 -
Mater Today Bio
Mannosylated graphene oxide nanotherapeutics co-delivering docetaxel and a STING agonist reprogram myeloid cells and potentiate antitumor immunity. [Abstract]2026 Mar 31:38:103086. PMID: 42006712 -
Cell Biosci
Tumor-derived interleukin-1 receptor antagonist exhibits immunosuppressive functions and promotes pancreatic cancer. [Abstract]2023 Aug 10;13(1):147. PMID: 37563620 -
J Mol Cell Biol
Microtubule-associated CCDC112 is essential for spermiogenesis and male fertility in mice. [Abstract]2026 Jun 25:mjag019. PMID: 42348320 -
Int J Mol Sci
Melatonin Rescues Heat Stress-Induced Suppression of TCA Cycle and Mitochondrial Damage in Goat Sertoli Cells. [Abstract]2025 Nov 27;26(23):11475. PMID: 41373630 -
Cell Oncol (Dordr)
GALNT6 drives lenvatinib resistance in hepatocellular carcinoma through autophagy and cancer-associated fibroblast activation. [Abstract]2024 Dec;47(6):2439-2460. PMID: 39718738 -
Reproduction
2026 Jan 15;171(1):xaaf013. PMID: 41575147 -
Oral Dis
2026 Apr 15. PMID: 41986910 -
Drug Dev Ind Pharm
Multiple stimulus-response berberine plus baicalin micelles with particle size-charge-release triple variable properties for breast cancer therapy. [Abstract]2023 Feb;49(2):189-206. PMID: 36971392 -
Vet Med Int
Sericin Supplementation Prior to and During In Vitro Maturation Mitigates H2O2-Induced Oxidative Stress in Bovine Oocytes. [Abstract]2026 May 21:2026:6119294. PMID: 42180161
Solvent & Solubility
H2O : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hyaluronidase, Ovine testes Related Classifications
HY-108903A Related Classifications
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