Succinate/succinate receptor antagonist 1

Name: Succinate/succinate receptor antagonist 1
Brand: MedChemExpress
SKU: HY-150205
Rating: 4.5 (0 reviews)

Cat. No.: HY-150205 Pureté: 99.40%: Fiche technique
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Succinate/succinate receptor antagonist 1 is an antagonist of the succinate/succinate receptor. Succinate/succinate receptor antagonist 1 can inhibit the activation of succinate receptor 1 (SUCNR1). Succinate/succinate receptor antagonist 1 can block succinate signaling. Succinate/succinate receptor antagonist 1 can be used for the study of periodontal disease.

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Succinate/succinate receptor antagonist 1 Chemical Structure

CAS No. : 2361972-29-2

Size	Stock	Quantité

Échantillon gratuit (0.1 - 0.2 mg)	Appliquer maintenant
Échantillon gratuit (0.1 - 0.2 mg)	Appliquer maintenant
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtenir un devis
500 mg	Obtenir un devis

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Description

In Vitro

Succinate/succinate receptor antagonist 1 (compound 7a) (10 μM; 24 h) significantly inhibits SUCNR1 activation and blocks succinate‑mediated receptor signaling in human SUCNR1 AequoScreen cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

277.32

Formule

C₁₇H₁₅N₃O

CAS No.

2361972-29-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC)CC1=CC=C(C2=NC3=NC=CC=C3C=C2)C=C1

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvant et solubilité

In Vitro:

DMSO : 25 mg/mL (90.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6059 mL	18.0297 mL	36.0594 mL
5 mM	0.7212 mL	3.6059 mL	7.2119 mL
10 mM	0.3606 mL	1.8030 mL	3.6059 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (7.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (7.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (7.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureté et documentation

Purity: 99.40%

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Fiche technique (269 KB) SDS (252 KB)

COA (246 KB) HNMR (264 KB) LCMS (107 KB)

Instruction de manipulation (2659 KB)

Références

[1]. LI, Xin, et al. Periodontal disease therapy. WO2019136022A1. 2019-07-11.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6059 mL	18.0297 mL	36.0594 mL	90.1486 mL
	5 mM	0.7212 mL	3.6059 mL	7.2119 mL	18.0297 mL
	10 mM	0.3606 mL	1.8030 mL	3.6059 mL	9.0149 mL
	15 mM	0.2404 mL	1.2020 mL	2.4040 mL	6.0099 mL
	20 mM	0.1803 mL	0.9015 mL	1.8030 mL	4.5074 mL
	25 mM	0.1442 mL	0.7212 mL	1.4424 mL	3.6059 mL
	30 mM	0.1202 mL	0.6010 mL	1.2020 mL	3.0050 mL
	40 mM	0.0901 mL	0.4507 mL	0.9015 mL	2.2537 mL
	50 mM	0.0721 mL	0.3606 mL	0.7212 mL	1.8030 mL
	60 mM	0.0601 mL	0.3005 mL	0.6010 mL	1.5025 mL
	80 mM	0.0451 mL	0.2254 mL	0.4507 mL	1.1269 mL