NF-56-EJ40 hydrochloride
Based on 14 publication(s) in Google Scholar
NF-56-EJ40 hydrochloride is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 hydrochloride has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM.
For research use only. We do not sell to patients.
- Purity: 98.45%
- CAS No.: 2728500-80-7
- Formula: C27H31Cl2N3O3
- Molecular Weight:516.46
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) NF-56-EJ40 hydrochloride
More- J Clin Invest. 2026 Jun 15;136(12):e200316. [Abstract]
- J Clin Invest. 2024 May 7:e173214. [Abstract]
- Cardiovasc Res. 2024 Nov 25;120(14):1693-1712. [Abstract]
- Sci Adv. 2026 Jun 12;12(24):eaec8873. [Abstract]
- Metabolism. 2023 Aug:145:155630. [Abstract]
- Cancer Lett. 2022 Feb 1:526:91-102. [Abstract]
- Dev Cell. 2022 Sep 26;57(18):2221-2236.e5. [Abstract]
- Arch Pharm Res. 2025 Aug;48(7-8):782-797. [Abstract]
- J Agric Food Chem. 2024 Sep 25;72(38):21052-21064. [Abstract]
- J Physiol. 2025 Mar 31. [Abstract]
- Poult Sci. 2024 Dec 31;104(2):104754. [Abstract]
- Oncol Res. 2026 Jan 19;34(2):25. [Abstract]
- Cell Signal. 2025 Sep 10:136:112127. [Abstract]
- bioRxiv. January 10, 2022.
Biological Activity
Chemical Information
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CAS No. 2728500-80-7
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Appearance Solid
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Molecular Weight 516.46
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Formula C27H31Cl2N3O3
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Color Off-white to light brown
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SMILES
O=C(NC1=C(CC(O)=O)C=CC=C1)C2=CC=CC(C3=CC=C(CN4CCN(C)CC4)C=C3)=C2.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (14)
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Journal Impact Factor
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Most Recent
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J Clin Invest
2026 Jun 15;136(12):e200316. PMID: 42294897 -
J Clin Invest
SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes. [Abstract]2024 May 7:e173214. PMID: 38713514 -
Cardiovasc Res
miR-369-3p ameliorates diabetes-associated atherosclerosis by regulating macrophage succinate-GPR91 signaling. [Abstract]2024 Nov 25;120(14):1693-1712. PMID: 38703377 -
Sci Adv
SUCNR1 coordinates metabolic flux, mitochondrial function, and nutrient-dependent adaptation in hepatocytes. [Abstract]2026 Jun 12;12(24):eaec8873. PMID: 42284407 -
Metabolism
2023 Aug:145:155630. PMID: 37315889 -
Cancer Lett
Succinate receptor 1 inhibits mitochondrial respiration in cancer cells addicted to glutamine. [Abstract]2022 Feb 1:526:91-102. PMID: 34813893 -
Dev Cell
Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction. [Abstract]2022 Sep 26;57(18):2221-2236.e5. PMID: 36108628 -
Arch Pharm Res
Silybin inhibits succinate production and secretion in hepatocytes to reverse liver fibrosis. [Abstract]2025 Aug;48(7-8):782-797. PMID: 40739373 -
J Agric Food Chem
Exposure to Succinate Leads to Steatosis in Non-Obese Non-Alcoholic Fatty Liver Disease by Inhibiting AMPK/PPARα/FGF21-Dependent Fatty Acid Oxidation. [Abstract]2024 Sep 25;72(38):21052-21064. PMID: 39268842 -
J Physiol
Impaired angiogenesis in gestational diabetes is linked to succinate/SUCNR1 axis dysregulation in late gestation. [Abstract]2025 Mar 31. PMID: 40163642 -
Poult Sci
Lactobacillus salivarius metabolite succinate enhances chicken intestinal stem cell activities via the SUCNR1-mitochondria axis. [Abstract]2024 Dec 31;104(2):104754. PMID: 39764876 -
Oncol Res
SDHA Deficiency in Hepatocellular Carcinoma Promotes Tumor Progression through Succinate-Induced M2 Macrophage Polarization. [Abstract]2026 Jan 19;34(2):25. PMID: 41613800 -
Cell Signal
GPR91 mediates low shear stress-induced endothelial ferroptosis via EGR1-dependent GPX4 repression. [Abstract]2025 Sep 10:136:112127. PMID: 40939914 -
Solvent & Solubility
DMSO : 5.19 mg/mL (10.05 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9363 mL | 9.6813 mL | 19.3626 mL | 48.4065 mL |
| 5 mM | 0.3873 mL | 1.9363 mL | 3.8725 mL | 9.6813 mL | |
| 10 mM | 0.1936 mL | 0.9681 mL | 1.9363 mL | 4.8406 mL |
NF-56-EJ40 hydrochloride Related Classifications
HY-130246A Related Classifications
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