1. Anti-infection
  2. SARS-CoV
  3. 4'-O-Methylbavachalcone

4'-O-Methylbavachalcone 

Cat. No.: HY-N1910 Purity: 99.64%
Handling Instructions

4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC50 of 10.1 μM.

For research use only. We do not sell to patients.

4'-O-Methylbavachalcone Chemical Structure

4'-O-Methylbavachalcone Chemical Structure

CAS No. : 20784-60-5

Size Price Stock Quantity
5 mg USD 168 In-stock
Estimated Time of Arrival: December 31
10 mg USD 286 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC50 of 10.1 μM[1].

IC50 & Target

IC50: 10.1 μM (PLpro)[1]

Molecular Weight

338.40

Formula

C₂₁H₂₂O₄

CAS No.

20784-60-5

SMILES

O=C(C1=CC(C/C=C(C)\C)=C(OC)C=C1O)/C=C/C2=CC=C(O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (147.75 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9551 mL 14.7754 mL 29.5508 mL
5 mM 0.5910 mL 2.9551 mL 5.9102 mL
10 mM 0.2955 mL 1.4775 mL 2.9551 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (7.39 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (6.15 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.64%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

4'-O-MethylbavachalconeSARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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Product Name:
4'-O-Methylbavachalcone
Cat. No.:
HY-N1910
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