298-46-4
298-46-4
Chemical Structure
Carbamazepine
Synonym(s): CBZ; NSC 169864
- CAS No.: 298-46-4
- Formula:C15H12N2O
- Molecular Weight:236.27
IUPAC Name: 5H-dibenzo[b,f]azepine-5-carboxamide
InChIKey: FFGPTBGBLSHEPO-UHFFFAOYSA-N
SMILES: O=C(N1C2=CC=CC=C2C=CC3=CC=CC=C31)N
Biological Activity: Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC50 of 131 μM. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50: 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Carbamazepine | 99.90% | Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC50 of 131 μM. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50: 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain. | ||||||||||||||||||||
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Carbamazepine (Standard) | 99.97% | Carbamazepine (Standard) is the analytical standard of Carbamazepine. This product is intended for research and analytical applications. Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC50 of 131 μM. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50: 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain. | ||||||||||||||||||||
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Carbamazepine-(Ph)d8 | 98.70% | Carbamazepine-(Ph)d8 (CBZ-(Ph)d8; NSC 169864-(Ph)d8) is the deuterium labeled Carbamazepine-(Ph) (HY-B0246). | ||||||||||||||||||||
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Carbamazepine-d4 | 99.72% | Carbamazepine-d4 (CBZ-d4) is the deuterium labeled Carbamazepine (HY-B0246). Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC50 of 131 μM. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50: 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain. | ||||||||||||||||||||
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Carbamazepine-d10 | 99.24% | Carbamazepine-d10 is the deuterium labeled Carbamazepine. Carbamazepine (CBZ), a sodium channel blocker, is an anticonvulsant agent. | ||||||||||||||||||||
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Carbamazepine-d8 | Carbamazepine-d8 is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent, with an IC50 of 131 μM. | |||||||||||||||||||||
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Carbamazepine-d2 | Carbamazepine-d2 is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent. | |||||||||||||||||||||
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Carbamazepine-d2,15N | Carbamazepine-d2,15N is a deuterated labeled Carbamazepine-d2,15N. | |||||||||||||||||||||
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References
- [1]. Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22(3): p. 627-35. [Content Brief]
- [2]. Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28(2): p. 143-53. [Content Brief]
- [3]. Beutler AS, et al. Carbamazepine is an inhibitor of histone deacetylases. Life Sci. 2005 May 13;76(26):3107-15. [Content Brief]
