Carbamazepine-d₈ (Synonyms: CBZ-d₈; NSC 169864-d₈)

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Carbamazepine-d₈ is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent, with an IC50 of 131 μM[1][2].

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Carbamazepine-d<sub>8</sub> Chemical Structure

Carbamazepine-d₈ Chemical Structure

CAS No. : 1538624-35-9

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Description	Carbamazepine-d₈ is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent, with an IC50 of 131 μM[1][2].
Molecular Weight	244.32
Formula	C₁₅H₄D₈N₂O
CAS No.	1538624-35-9
SMILES	NC(N1C2=C([2H])C([2H])=C([2H])C=C2C([2H])=C([2H])C3=CC([2H])=C([2H])C([2H])=C31)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (274 KB) Handling Instructions (2659 KB)
References	[1]. Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22(3): p. 627-35. [Content Brief] [2]. Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28(2): p. 143-53. [Content Brief] [3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carbamazepine-d₈1538624-35-9CBZ-d₈NSC 169864-d₈Sodium ChannelAutophagyMitophagyNa channelsNa+ channelsMitochondrial AutophagyInhibitorinhibitorinhibit

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Carbamazepine-d8 (Synonyms: CBZ-d8; NSC 169864-d8)

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