Carbamazepine-d10
Based on 1 Customer Validation
Carbamazepine-d10 is the deuterium labeled Carbamazepine. Carbamazepine (CBZ), a sodium channel blocker, is an anticonvulsant agent.
For research use only. We do not sell to patients.
- Purity: 99.24%
- CAS No.: 132183-78-9
- Formula: C15H2D10N2O
- Molecular Weight:246.33
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 132183-78-9
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Unlabeled Cas 298-46-4
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Appearance Solid
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Molecular Weight 246.33
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Formula C15H2D10N2O
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Color White to off-white
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SMILES
NC(N1C2=C([2H])C([2H])=C([2H])C([2H])=C2C([2H])=C([2H])C3=C([2H])C([2H])=C([2H])C([2H])=C31)=O
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Synonyms
CBZ-d10; NSC 169864-d10
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (202.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (736 KB)
- English - EN (736 KB)
- Français - FR (736 KB)
- Deutsch - DE (736 KB)
- Norwegian - NO (736 KB)
- Español - ES (736 KB)
- Swedish - SV (736 KB)
- Italian - IT (736 KB)
- Korean - KR (736 KB)
- Portuguese - PT (736 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22(3): p. 627-35. [Content Brief]
[3]. Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28(2): p. 143-53. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0596 mL | 20.2980 mL | 40.5959 mL | 101.4899 mL |
| 5 mM | 0.8119 mL | 4.0596 mL | 8.1192 mL | 20.2980 mL | |
| 10 mM | 0.4060 mL | 2.0298 mL | 4.0596 mL | 10.1490 mL | |
| 15 mM | 0.2706 mL | 1.3532 mL | 2.7064 mL | 6.7660 mL | |
| 20 mM | 0.2030 mL | 1.0149 mL | 2.0298 mL | 5.0745 mL | |
| 25 mM | 0.1624 mL | 0.8119 mL | 1.6238 mL | 4.0596 mL | |
| 30 mM | 0.1353 mL | 0.6766 mL | 1.3532 mL | 3.3830 mL | |
| 40 mM | 0.1015 mL | 0.5074 mL | 1.0149 mL | 2.5372 mL | |
| 50 mM | 0.0812 mL | 0.4060 mL | 0.8119 mL | 2.0298 mL | |
| 60 mM | 0.0677 mL | 0.3383 mL | 0.6766 mL | 1.6915 mL | |
| 80 mM | 0.0507 mL | 0.2537 mL | 0.5074 mL | 1.2686 mL | |
| 100 mM | 0.0406 mL | 0.2030 mL | 0.4060 mL | 1.0149 mL |
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