2. Others MAPK/ERK Pathway Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Biochemical Assay Reagents p38 MAPK Potassium Channel Mitochondrial Metabolism
  4. Ac4ManNAz

Ac4ManNAz can be taken up by cells and is an azide-containing metabolic glycoprotein labeling reagent that selectively modifies proteins. Commonly used for cell labeling, tracking and proteomic analysis. Ac4ManNAz contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Ac4ManNAz can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

CAS No. : 1213701-11-1

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Customer Review

Based on 14 publication(s) in Google Scholar

Other Forms of Ac4ManNAz:

Ac4ManNAz Related Antibodies

Top Publications Citing Use of Products

    Ac4ManNAz purchased from MedChemExpress. Usage Cited in: Adv Mater. 2025 Jul 7:e2504733.  [Abstract]

    Scheme illustration of the preparation of tumor-lysate pulsed DC vaccines (DCVs). BMDCs were incubated with 50 μM Ac4ManNAz and tumor lysates for 48 h.

    Ac4ManNAz purchased from MedChemExpress. Usage Cited in: Int J Nanomedicine. 2025 Nov 26:20:14185-14200.  [Abstract]

    Ac4ManNAz (50 μM; 72 h). qRT-PCR analysis comparing the relative expression level of IL-1β between M1 macrophages and Ac4ManNAz-treated M1 macrophages (Ac4/M1).

    Ac4ManNAz purchased from MedChemExpress. Usage Cited in: Int J Nanomedicine. 2025 Nov 26:20:14185-14200.  [Abstract]

    Ac4ManNAz (50 μM; 72 h). Fluorescence microscopy imaging of macrophages labeled with DBCO-Cy5 after Ac4ManNAz treatment. Hoechst staining shows nuclei (blue), while DBCO-Cy5 indicates successful surface labeling (red). The merged image highlights specific azide-dependent bioorthogonal chemistry, with scale bars representing 100 µm.

    Ac4ManNAz purchased from MedChemExpress. Usage Cited in: Int J Nanomedicine. 2025 Nov 26:20:14185-14200.  [Abstract]

    Ac4ManNAz (50 μM; 72 h). Morphological comparison of M0, M1, and Ac4ManNAz-treated M1 macrophages.

    Ac4ManNAz purchased from MedChemExpress. Usage Cited in: Int J Nanomedicine. 2025 Nov 26:20:14185-14200.  [Abstract]

    Ac4ManNAz (50 μM; 72 h). qRT-PCR results showing that with Ac4ManNAz-treated M1EV (Ac4M1EV) significantly upregulated M1 macrophage markers IL-1β and CXCL10, while downregulating the M2 macrophage marker CD206 compared with M0 macrophages.

    View All p38 MAPK Isoform Specific Products:

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    p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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    • Customer Review

    Description

    Ac4ManNAz can be taken up by cells and is an azide-containing metabolic glycoprotein labeling reagent that selectively modifies proteins. Commonly used for cell labeling, tracking and proteomic analysis. Ac4ManNAz contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Ac4ManNAz can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

    In Vitro

    Ac4ManNAz (0-50 μM, 72 h) upregulates MAPK activity-related genes (TLR4, THBS1, FPR1) and downregulates cell cycle, proliferation and cell adhesion-related genes like CYBB, GABRA1, SLC6A2, AKAP7)[2].
    Ac4ManNAz (0-50 μM, 30 h) inhibits voltage-gated potassium channel, inhibits the cell migration and invasion in A549, and impairs the mitochondrial functions[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ac4ManNAz Related Antibodies

    Cell Migration Assay [2]

    Cell Line: A549
    Concentration: 50 μM
    Incubation Time: 30 h
    Result: Inhibited cell migration.
    Molecular Weight

    430.37

    Formula

    C16H22N4O10
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CC(O[C@@H]1[C@@H]([C@H](O[C@@H]([C@H]1OC(C)=O)COC(C)=O)OC(C)=O)NC(CN=[N+]=[N-])=O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (232.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3236 mL 11.6179 mL 23.2358 mL
    5 mM 0.4647 mL 2.3236 mL 4.6472 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.52%

    SDS (393 KB)

    COA (253 KB) HNMR (270 KB) LCMS (89 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3236 mL 11.6179 mL 23.2358 mL 58.0896 mL
    5 mM 0.4647 mL 2.3236 mL 4.6472 mL 11.6179 mL
    10 mM 0.2324 mL 1.1618 mL 2.3236 mL 5.8090 mL
    15 mM 0.1549 mL 0.7745 mL 1.5491 mL 3.8726 mL
    20 mM 0.1162 mL 0.5809 mL 1.1618 mL 2.9045 mL
    25 mM 0.0929 mL 0.4647 mL 0.9294 mL 2.3236 mL
    30 mM 0.0775 mL 0.3873 mL 0.7745 mL 1.9363 mL
    40 mM 0.0581 mL 0.2904 mL 0.5809 mL 1.4522 mL
    50 mM 0.0465 mL 0.2324 mL 0.4647 mL 1.1618 mL
    60 mM 0.0387 mL 0.1936 mL 0.3873 mL 0.9682 mL
    80 mM 0.0290 mL 0.1452 mL 0.2904 mL 0.7261 mL
    100 mM 0.0232 mL 0.1162 mL 0.2324 mL 0.5809 mL
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    Ac4ManNAz Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ac4ManNAz1213701-11-1Biochemical Assay Reagentsp38 MAPKPotassium ChannelMitochondrial MetabolismKcsAInhibitorinhibitorinhibit

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