A2AR/A2BR antagonist 1
A2AR/A2BR antagonist 1 (compound 7ai) has a dual antagonistic effect on A2AR/A2BR, with the IC50 values of 11.2 nM and 6.4 nM for A2AR and A2BR, respectively. A2AR/A2BR antagonist 1 promotes T cell-mediated cancer cell death.
For research use only. We do not sell to patients.
- Formula: C24H17N9
- Molecular Weight:431.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
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A2AR 11.2 nM (IC50) |
A2BR 6.4 nM (IC50) |
A2AR/A2BR antagonist 1 (compound 7ai) (0.1, 1, 10 μM, 0-48 h) can reverse NECA (HY-103173)-mediated immunosuppression, profoundly promote the activation and killing ability of OT-I CTL cells, thereby exerting anti-cancer activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human Jurkat T cells
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Concentration:0.1, 1, 10 μM
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Incubation Time:0-48 h
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Result:Almost completely abolished NECA (HY-103173)-induced upregulation of expression of immunosuppressive molecules (PD-1 and TIM-3).
Chemical Information
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Molecular Weight 431.45
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Formula C24H17N9
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SMILES
NC1=NC(C2=CN(N=N2)CC3=CNC4=C3C=C(C=C4)C#N)=CC(C5=CC=CC(C#N)=C5C)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
A2AR/A2BR antagonist 1 Related Classifications
HY-158057 Related Classifications
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