2. GPCR/G Protein
  3. Adenosine Receptor
  4. PSB36

PSB36 is a potent and selective antagonist of adenosine A1 receptor, with Kis 0.12 nM, 187 nM, 552 nM, 2300 nM, and 6500 nM for rA1, hA2B, rA2A, hA3 and rA3 receptors respectively. PSB36 can be used for the research of hyperalgesia.

For research use only. We do not sell to patients.

PSB36 Chemical Structure

PSB36 Chemical Structure

CAS No. : 524944-72-7

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5 mg USD 710 In-stock
10 mg USD 1150 In-stock
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Based on 1 publication(s) in Google Scholar

PSB36 Related Antibodies

Top Publications Citing Use of Products

View All Adenosine Receptor Isoform Specific Products:

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

PSB36 is a potent and selective antagonist of adenosine A1 receptor, with Kis 0.12 nM, 187 nM, 552 nM, 2300 nM, and 6500 nM for rA1, hA2B, rA2A, hA3 and rA3 receptors respectively. PSB36 can be used for the research of hyperalgesia[1][2].

IC50 & Target[1]

rA1

0.12 nM (Ki)

hA2B

187 nM (Ki)

rA2A

552 nM (Ki)

hA3

2300 nM (Ki)

rA3

6500 nM (Ki)

Molecular Weight

386.49

Formula

C21H30N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCCC)N(CCCO)C2=C(N=C(C34CC(C5)CC3CC5C4)N2)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 20 mg/mL (51.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5874 mL 12.9369 mL 25.8739 mL
5 mM 0.5175 mL 2.5874 mL 5.1748 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5874 mL 12.9369 mL 25.8739 mL 64.6847 mL
5 mM 0.5175 mL 2.5874 mL 5.1748 mL 12.9369 mL
10 mM 0.2587 mL 1.2937 mL 2.5874 mL 6.4685 mL
15 mM 0.1725 mL 0.8625 mL 1.7249 mL 4.3123 mL
20 mM 0.1294 mL 0.6468 mL 1.2937 mL 3.2342 mL
25 mM 0.1035 mL 0.5175 mL 1.0350 mL 2.5874 mL
30 mM 0.0862 mL 0.4312 mL 0.8625 mL 2.1562 mL
40 mM 0.0647 mL 0.3234 mL 0.6468 mL 1.6171 mL
50 mM 0.0517 mL 0.2587 mL 0.5175 mL 1.2937 mL
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PSB36 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSB36524944-72-7PSB 36PSB-36Adenosine ReceptorP1 receptorInhibitorinhibitorinhibit

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