2. GPCR/G Protein
  3. Adenosine Receptor
  4. ST 1535

ST 1535 is a potent and orally active A2A adenosine receptor antagonist. ST 1535 shows antiparkinsonian activity and antitremorigenic effects. ST 1535 has the potential for the research of Parkinson’s disease.

For research use only. We do not sell to patients.

ST 1535 Chemical Structure

ST 1535 Chemical Structure

CAS No. : 496955-42-1

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ST 1535 Related Antibodies

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Description

ST 1535 is a potent and orally active A2A adenosine receptor antagonist. ST 1535 shows antiparkinsonian activity and antitremorigenic effects. ST 1535 has the potential for the research of Parkinson’s disease[1][2].

IC50 & Target[1]

A2a adenosine receptor

 

In Vitro

ST 1535 (0-1000 nM) inhibits forskolin (HY-15371)-induced cAMP formation in CHO cells with IC50s of 510, 353, 950, >1000 nM for hA1, hA2A, hA2B, hA3, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ST 1535 Related Antibodies
In Vivo

ST 1535 (0, 5, 10 mg/kg; p.o.) antagonizes catalepsy induced by i.c.v. administration with the A2A adenosine agonist CGS 21680 (HY-13201)[1].
ST 1535 (10, 20, 40 mg/kg; i.p.) increases the number of contralateral turns induced by l-DOPA (HY-N0304) in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-6 weeks CD1 male mice[1]
Dosage: 0, 5, 10 mg/kg
Administration: P.o.
Result: Antagonized catalepsy induced by i.c.v. administration with the A2A adenosine agonist CGS 21680.
Animal Model: Male Sprague Dawley rats[2]
Dosage: 10, 20, 40 mg/kg
Administration: I.p.
Result: Significantly increased the number of contralateral turns induced by l-DOPA (3 mg/kg i.p.) at 20 and 40 mg/kg.
Molecular Weight

272.31

Formula

C12H16N8
CAS No.
SMILES

CN1C(N2N=CC=N2)=NC3=C1N=C(CCCC)N=C3N
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ST 1535 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ST 1535496955-42-1ST1535ST-1535Adenosine ReceptorP1 receptororally activeantiparkinsonianantitremorigenicParkinson’s diseaseInhibitorinhibitorinhibit

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