2. GPCR/G Protein
  3. Adenosine Receptor
  4. Adenosine receptor antagonist 2

Adenosine receptor antagonist 2 

Cat. No.: HY-144064 Purity: 99.37%
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Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity.

For research use only. We do not sell to patients.

Adenosine receptor antagonist 2 Chemical Structure

Adenosine receptor antagonist 2 Chemical Structure

CAS No. : 2703054-47-9

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5 mg USD 780 In-stock
10 mg USD 1250 In-stock
25 mg USD 2500 In-stock
50 mg USD 4050 In-stock
100 mg USD 6500 In-stock
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Based on 1 publication(s) in Google Scholar

Adenosine receptor antagonist 2 Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity[1].

IC50 & Target[1]

A2a adenosine receptor

1 nM (IC50)

A2b adenosine receptor

3 nM (IC50)

In Vivo

Adenosine receptor antagonist 2 (compound L-1; po; 10, 30, 100 mg/kg; twice a day for 22 days) inhibits tumor growth in female C57BL / 6mice mice with MC38(#22)-hpd-L1 cells[1].
Adenosine receptor antagonist 2 (iv; 2 mg/kg) has a CLz of 14.7 mL/min·kg and an AUC of 2252 h·ng/mL. Adenosine receptor antagonist 2 (po; 10 mg/kg) has a Cmax of 8730 ng/mL in adult male ICR mice (weight 25-40g)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

444.46

Formula

C23H21FN8O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC=CC(C2=NC(C3=CN(CC4=CC=CC(C(C)(C)O)=N4)N=N3)=C(F)C(N)=N2)=C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (224.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2499 mL 11.2496 mL 22.4992 mL
5 mM 0.4500 mL 2.2499 mL 4.4998 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2499 mL 11.2496 mL 22.4992 mL 56.2480 mL
5 mM 0.4500 mL 2.2499 mL 4.4998 mL 11.2496 mL
10 mM 0.2250 mL 1.1250 mL 2.2499 mL 5.6248 mL
15 mM 0.1500 mL 0.7500 mL 1.4999 mL 3.7499 mL
20 mM 0.1125 mL 0.5625 mL 1.1250 mL 2.8124 mL
25 mM 0.0900 mL 0.4500 mL 0.9000 mL 2.2499 mL
30 mM 0.0750 mL 0.3750 mL 0.7500 mL 1.8749 mL
40 mM 0.0562 mL 0.2812 mL 0.5625 mL 1.4062 mL
50 mM 0.0450 mL 0.2250 mL 0.4500 mL 1.1250 mL
60 mM 0.0375 mL 0.1875 mL 0.3750 mL 0.9375 mL
80 mM 0.0281 mL 0.1406 mL 0.2812 mL 0.7031 mL
100 mM 0.0225 mL 0.1125 mL 0.2250 mL 0.5625 mL
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Adenosine receptor antagonist 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adenosine receptor antagonist 22703054-47-9Adenosine receptor antagonist2Adenosine receptor antagonist-2Adenosine ReceptorP1 receptororallyMC38(#22)-hpd-L1A2a/A2b adenosine receptorInhibitorinhibitorinhibit

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