Adenosine receptor antagonist 2
Based on 1 Customer Validation
Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity.
For research use only. We do not sell to patients.
- Purity: 99.37%
- CAS No.: 2703054-47-9
- Formula: C23H21FN8O
- Molecular Weight:444.46
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Adenosine Receptor Isoforms
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Biological Activity
|
A2a adenosine receptor 1 nM (IC50) |
A2b adenosine receptor 3 nM (IC50) |
Adenosine receptor antagonist 2 (iv; 2 mg/kg) has a CLz of 14.7 mL/min·kg and an AUC of 2252 h·ng/mL. Adenosine receptor antagonist 2 (po; 10 mg/kg) has a Cmax of 8730 ng/mL in adult male ICR mice (weight 25-40g)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2703054-47-9
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Appearance Solid
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Molecular Weight 444.46
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Formula C23H21FN8O
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Color White to off-white
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SMILES
N#CC1=CC=CC(C2=NC(C3=CN(CC4=CC=CC(C(C)(C)O)=N4)N=N3)=C(F)C(N)=N2)=C1C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (224.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2499 mL | 11.2496 mL | 22.4992 mL | 56.2480 mL |
| 5 mM | 0.4500 mL | 2.2499 mL | 4.4998 mL | 11.2496 mL | |
| 10 mM | 0.2250 mL | 1.1250 mL | 2.2499 mL | 5.6248 mL | |
| 15 mM | 0.1500 mL | 0.7500 mL | 1.4999 mL | 3.7499 mL | |
| 20 mM | 0.1125 mL | 0.5625 mL | 1.1250 mL | 2.8124 mL | |
| 25 mM | 0.0900 mL | 0.4500 mL | 0.9000 mL | 2.2499 mL | |
| 30 mM | 0.0750 mL | 0.3750 mL | 0.7500 mL | 1.8749 mL | |
| 40 mM | 0.0562 mL | 0.2812 mL | 0.5625 mL | 1.4062 mL | |
| 50 mM | 0.0450 mL | 0.2250 mL | 0.4500 mL | 1.1250 mL | |
| 60 mM | 0.0375 mL | 0.1875 mL | 0.3750 mL | 0.9375 mL | |
| 80 mM | 0.0281 mL | 0.1406 mL | 0.2812 mL | 0.7031 mL | |
| 100 mM | 0.0225 mL | 0.1125 mL | 0.2250 mL | 0.5625 mL |
Adenosine receptor antagonist 2 Related Classifications
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