1. GPCR/G Protein
  2. Adenosine Receptor
  3. Derenofylline

Derenofylline (Synonyms: SLV 320)

Cat. No.: HY-14858 Purity: >99.0%
Handling Instructions

Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats.

For research use only. We do not sell to patients.

Derenofylline Chemical Structure

Derenofylline Chemical Structure

CAS No. : 251945-92-3

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1].

IC50 & Target

Ki: 1 nM (adenosine A1 receptor)[1].

Clinical Trial
Molecular Weight

308.38

Formula

C₁₈H₂₀N₄O

CAS No.

251945-92-3

SMILES

O[[email protected]]1CC[[email protected]](NC2=C3C(NC=C3)=NC(C4=CC=CC=C4)=N2)CC1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Derenofylline
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