251945-92-3
Chemical Structure
Derenofylline
Synonym(s): SLV 320
- CAS No.: 251945-92-3
- Formula:C18H20N4O
- Molecular Weight:308.38
IUPAC Name: (1r,4r)-4-((2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexan-1-ol
InChIKey: RBZNJGHIKXAKQE-HDJSIYSDSA-N
SMILES: O[C@H]1CC[C@H](NC2=C3C(NC=C3)=NC(C4=CC=CC=C4)=N2)CC1
Biological Activity: Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Derenofylline | 99.70% | Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Derenofylline (Standard) | ≥98% | Derenofylline (Standard) is the analytical standard of Derenofylline. This product is intended for research and analytical applications. Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.61
HY-143490PAK4-IN-2 -
Similarity Score 0.54
HY-75368SRI-31255 -
Similarity Score 0.51
HY-131976BVDV-IN-1 -
Similarity Score 0.51
HY-165360JJ1 -
Similarity Score 0.51
HY-11055KP 544 -
Similarity Score 0.50
HY-164619CDK9-IN-34 -
Similarity Score 0.50
HY-147313TH10785 -
Similarity Score 0.50
HY-112392GSK-3 Inhibitor XIII -
Similarity Score 0.50
HY-147149BPN-15477 -
Explore the MedChemAI to find more analogs
