1. JAK/STAT Signaling
    Stem Cell/Wnt
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  3. Ochromycinone

Ochromycinone (Synonyms: (Rac)-STA-21)

Cat. No.: HY-18061 Purity: 98.29%
Handling Instructions

Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity.

For research use only. We do not sell to patients.

Ochromycinone Chemical Structure

Ochromycinone Chemical Structure

CAS No. : 111540-00-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 440 In-stock
Estimated Time of Arrival: December 31
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 680 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3400 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Ochromycinone

    Ochromycinone purchased from MCE. Usage Cited in: Nutrients. 2016 May 11;8(5). pii: E280.

    Levels of p-STAT3 are determined by Western blotting and the levels of IL-6 and IL-8 are determined by ELISA assay, in MΦ cultures. Effect of treatment with IL-1β, IL-6, aIL-6 or STA21. Co, control. Representative data from one of three experiments are shown.

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    Description

    Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity[1][2].

    IC50 & Target[2]

    STAT3

     

    In Vitro

    STA-21 inhibits STAT3 DNA binding activity, STAT3 dimerization, and STAT3-dependent luciferase activity. Moreover, STA-21 reduces the survival of breast carcinoma cells with constitutive STAT3 signaling but has minimal effect on the cells in which constitutive STAT3 signaling is absent[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    306.31

    Formula

    C₁₉H₁₄O₄

    CAS No.
    SMILES

    CC(CC1=O)CC2=C1C3=C(C=C2)C(C4=C(O)C=CC=C4C3=O)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 16.67 mg/mL (54.42 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2647 mL 16.3233 mL 32.6467 mL
    5 mM 0.6529 mL 3.2647 mL 6.5293 mL
    10 mM 0.3265 mL 1.6323 mL 3.2647 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 1.67 mg/mL (5.45 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    Ochromycinone(Rac)-STA-21STATBacterialSTAT3anticancerantibioticantimicrobialdimerizationDNAbindingInhibitorinhibitorinhibit

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    Product Name:
    Ochromycinone
    Cat. No.:
    HY-18061
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