1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. STAT5-IN-1

STAT5-IN-1 

Cat. No.: HY-101853 Purity: >98.0%
Handling Instructions

STAT5-IN-1 is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform.

For research use only. We do not sell to patients.

STAT5-IN-1 Chemical Structure

STAT5-IN-1 Chemical Structure

CAS No. : 285986-31-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
25 mg USD 228 In-stock
Estimated Time of Arrival: December 31
50 mg USD 408 In-stock
Estimated Time of Arrival: December 31
100 mg USD 720 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 6 publication(s) in Google Scholar

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Description

STAT5-IN-1 is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform.

IC50 & Target

STAT5β

47 μM (IC50)

In Vitro

The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 µM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members[1].

Molecular Weight

293.28

Formula

C₁₆H₁₁N₃O₃

CAS No.

285986-31-4

SMILES

O=C(C1=CC=CN=C1)N/N=C/C2=COC3=CC=CC=C3C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (68.19 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4097 mL 17.0486 mL 34.0971 mL
5 mM 0.6819 mL 3.4097 mL 6.8194 mL
10 mM 0.3410 mL 1.7049 mL 3.4097 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2 mg/mL (6.82 mM); Precipitated solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

STAT5-IN-1STATInhibitorinhibitorinhibit

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Product name:
STAT5-IN-1
Cat. No.:
HY-101853
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