1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. Stafib-1

Stafib-1 

Cat. No.: HY-112647 Purity: 95.04%
Handling Instructions

Stafib-1 is the first selective inhibitor of the STAT5b SH2 domain, with a Ki of 44 nM and an IC50 of 154 nM.

For research use only. We do not sell to patients.

Stafib-1 Chemical Structure

Stafib-1 Chemical Structure

CAS No. : 1688703-26-5

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Description

Stafib-1 is the first selective inhibitor of the STAT5b SH2 domain, with a Ki of 44 nM and an IC50 of 154 nM[1].

IC50 & Target[1]

STAT5b

154 nM (IC50)

In Vitro

Stafib-1 is the first small molecule which inhibits the STAT5b SH2 domain with more than 50-fold selectivity over STAT5a[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

602.42

Formula

C26H24N2O11P2

CAS No.
SMILES

O=C(C1=CC=C2C=C(OCC(NCC3=CC=C(OP(O)(O)=O)C(OP(O)(O)=O)=C3)=O)C=CC2=C1)NC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (166.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6600 mL 8.2999 mL 16.5997 mL
5 mM 0.3320 mL 1.6600 mL 3.3199 mL
10 mM 0.1660 mL 0.8300 mL 1.6600 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.15 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.15 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.15 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

References
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Product Name:
Stafib-1
Cat. No.:
HY-112647
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