1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. Stafia-1

Stafia-1 

Cat. No.: HY-136546
Handling Instructions

Stafia-1 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.

For research use only. We do not sell to patients.

Stafia-1 Chemical Structure

Stafia-1 Chemical Structure

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Description

Stafia-1 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members[1].

IC50 & Target[1]

STAT5a

10.9 μM (Ki)

STAT5a

22.2 μM (IC50)

In Vitro

Stafia-1 shows at least 9-fold selectivity over STAT5b and higher selectivity against other STAT family members[1].

Molecular Weight

506.44

Formula

C₂₄H₂₇O₁₀P

SMILES

OP(OC1=CC(C2=CC(OC)=C(OC)C(OC)=C2)=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C1)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Keywords:

Stafia-1Stafia1Stafia 1STATselectivityleukemiacellsSH2domainInhibitorinhibitorinhibit

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Stafia-1
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