1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. Stafia-1

Stafia-1 

Cat. No.: HY-136546 Purity: 99.53%
Handling Instructions

Stafia-1 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.

For research use only. We do not sell to patients.

Stafia-1 Chemical Structure

Stafia-1 Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 501 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

Stafia-1 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members[1].

IC50 & Target[1]

STAT5a

10.9 μM (Ki)

STAT5a

22.2 μM (IC50)

In Vitro

Stafia-1 shows at least 9-fold selectivity over STAT5b and higher selectivity against other STAT family members[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

506.44

Formula

C₂₄H₂₇O₁₀P

SMILES

OP(OC1=CC(C2=CC(OC)=C(OC)C(OC)=C2)=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C1)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (493.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9746 mL 9.8728 mL 19.7457 mL
5 mM 0.3949 mL 1.9746 mL 3.9491 mL
10 mM 0.1975 mL 0.9873 mL 1.9746 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.11 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.11 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Stafia-1Stafia1Stafia 1STATselectivityleukemiacellsSH2domainInhibitorinhibitorinhibit

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Product Name:
Stafia-1
Cat. No.:
HY-136546
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