116409-29-1
116409-29-1
Chemical Structure
NSC-370284
- CAS No.: 116409-29-1
- Formula:C21H25NO6
- Molecular Weight:387.43
IUPAC Name: 6-(pyrrolidin-1-yl(3,4,5-trimethoxyphenyl)methyl)benzo[d][1,3]dioxol-5-ol
InChIKey: QCXGNLZKUHBIHD-UHFFFAOYSA-N
SMILES: OC1=C(C(N2CCCC2)C3=CC(OC)=C(OC)C(OC)=C3)C=C(OCO4)C4=C1
Biological Activity: NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NSC-370284 | 99.27% | NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5. | ||||||||||||||||||||
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UC-514321 | 98.0% | UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity. | ||||||||||||||||||||
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(±)-ML 209 | 98.14% | (±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4+ T cells into other lineages, including Th1 and regulatory T cells. | ||||||||||||||||||||
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Autophagy inducer 4 | 99.63% | Autophagy inducer 4 is a Magnolol-based Mannich base derivatives, which can be used as an anticancer agent. Autophagy inducer 4 suppresses cancer cells via inducing autophagy. Autophagy inducer 4 has 76-fold improvement in cytotoxicity against T47D cells compared with Magnolol. Autophagy inducer 4 also possesses suppressive effects on migration of T47D and Hela cancer cells. | ||||||||||||||||||||
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HA-CD44 interaction inhibitor 2 | 99.36% | HA-CD44 interaction inhibitor 2 is a CD44 inhibitor that can inhibit the interaction between Hyaluronic acid (HA) (HY-B0633A) and CD44. HA-CD44 interaction inhibitor 2 acts as an antiproliferative agent against CD44+ cancer cells. HA-CD44 interaction inhibitor 2 can disrupt the integrity of cancer spheres and reduce cancer cell viability in a dose-dependent manner. HA-CD44 interaction inhibitor 2 is applicable for tumor research. | ||||||||||||||||||||
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AS15 | AS15 is a PDIA1 inhibitor with an IC50 value of 300 nM. AS15 interacts with the active-site cysteine of PDIA1, and this process is independent of the substrate-binding domain of PDIA1. AS15 acts as a synergistic cell growth inhibitor with buthionine sulfoximine (BSO) (HY-106376), a glutathione synthesis inhibitor. AS15 can be used in the research of glioblastoma. | |||||||||||||||||||||
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Sphenanlignan | Sphenanlignan is a natural product. | |||||||||||||||||||||
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Fagarine II | Fagarine II is an alkaloid found in the leaves and twigs of Fagara coco. Alkaloids are a large class of complex nitrogen-containing basic organic compounds. As food, nutritional supplements, and medicines, alkaloids play an important role in medicine and other fields. Alkaloid compounds exhibit good biological activities in anti-inflammatory, anticancer, analgesic, local anesthetic, neuropharmacological, antibacterial, and antifungal properties. | |||||||||||||||||||||
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RDR 03785 | 97.05% | RDR 03785 is a covalent MIF inhibitor with an IC50 of 0.36 μM. | ||||||||||||||||||||
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LDLR regulator-1 | 99.89% | LDLR regulator-1 (Compound 7b) is a regulator of the low-density lipoprotein receptor (LDLR), capable of increasing the mRNA expression of LDLR. | ||||||||||||||||||||
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Frataxin-IN-1 | Frataxin-in-1 (Compound (+)-11) is a Frataxin inhibitor with IC50 value of 45 μM, which can be used in the study of Friedreich's ataxia (FRDA). | |||||||||||||||||||||
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