2. Autophagy
  3. Autophagy
  4. Autophagy inducer 4

Autophagy inducer 4 is a Magnolol-based Mannich base derivatives, which can be used as an anticancer agent. Autophagy inducer 4 suppresses cancer cells via inducing autophagy. Autophagy inducer 4 has 76-fold improvement in cytotoxicity against T47D cells compared with Magnolol. Autophagy inducer 4 also possesses suppressive effects on migration of T47D and Hela cancer cells.

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Autophagy inducer 4 Chemical Structure

Autophagy inducer 4 Chemical Structure

CAS No. : 2486455-03-0

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Autophagy inducer 4 Related Antibodies

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Description

Autophagy inducer 4 is a Magnolol-based Mannich base derivatives, which can be used as an anticancer agent. Autophagy inducer 4 suppresses cancer cells via inducing autophagy. Autophagy inducer 4 has 76-fold improvement in cytotoxicity against T47D cells compared with Magnolol. Autophagy inducer 4 also possesses suppressive effects on migration of T47D and Hela cancer cells[1].

IC50 & Target

IC50: 0.91 μM in T47D, 3.32 μM in MCF-7, 1.71 μM in Hela[1]
In Vitro

Autophagy inducer 4 (compound 3p) (0-10 μM; 72 hours) displays highly potent antiproliferative activity against T47D, MCF-7 and Hela cell lines[1].
Autophagy inducer 4 (40-80 μM; 0-36 hours) significantly increases GFP-LC3 protein puncta with both dose- and time-dependent manners in HEK293 cells[1].
Autophagy inducer 4 (0-80 μM; 0-36 hours) increases the transformation of LC3-I into LC3-II in a dose- and time-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Autophagy inducer 4 Related Antibodies

Cell Proliferation Assay

Cell Line: T47D, MCF-7 and Hela cells[1]
Concentration: 0-10 μM
Incubation Time: 72 hours
Result: Displayed highly potent antiproliferative activity against T47D, MCF-7 and Hela cell lines with IC50 values of 0.91, 3.32 and 1.71 μM, respectively.

Cell Autophagy Assay

Cell Line: GFP-LC3-HEK293[1]
Concentration: 40, 60 and 80 μM
Incubation Time: 0, 12, 24 and 36 hours
Result: Significantly increased GFP-LC3 protein puncta with both dose- and time-dependent manners in HEK293 cells.

Western Blot Analysis

Cell Line: Hela, T47D and HEK293[1]
Concentration: 0, 5, 10 and 20 μM in T47D and Hela; 0, 40, 60 and 80 μM in HEK293
Incubation Time: 0, 12, 24 and 36 hours
Result: Increased the transformation of LC3-I into LC3-II in a dose-dependent manner, and enhanced the expression of LC3-II in a time-dependent manner.
Molecular Weight

531.64

Formula

C32H37NO6
CAS No.
SMILES

OC1=C(C2=CC(CC=C)=CC(C(N3CCOCC3)C4=CC(OC)=C(C(OC)=C4)OC)=C2O)C=C(CC=C)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Autophagy inducer 4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Autophagy inducer 42486455-03-0Autophagy inducer4Autophagy inducer-4AutophagyAnticancerMannich base derivativesT47DMCF-7HelaCell migrationCell proliferationInhibitorinhibitorinhibit

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