Autophagy inducer 4
Based on 1 Customer Validation
Autophagy inducer 4 is a Magnolol-based Mannich base derivatives, which can be used as an anticancer agent. Autophagy inducer 4 suppresses cancer cells via inducing autophagy. Autophagy inducer 4 has 76-fold improvement in cytotoxicity against T47D cells compared with Magnolol. Autophagy inducer 4 also possesses suppressive effects on migration of T47D and Hela cancer cells.
For research use only. We do not sell to patients.
- Purity: 99.63%
- CAS No.: 2486455-03-0
- Formula: C32H37NO6
- Molecular Weight:531.64
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.91 μM in T47D, 3.32 μM in MCF-7, 1.71 μM in Hela[1]
Autophagy inducer 4 (compound 3p) (0-10 μM; 72 hours) displays highly potent antiproliferative activity against T47D, MCF-7 and Hela cell lines[1].
Autophagy inducer 4 (40-80 μM; 0-36 hours) significantly increases GFP-LC3 protein puncta with both dose- and time-dependent manners in HEK293 cells[1].
Autophagy inducer 4 (0-80 μM; 0-36 hours) increases the transformation of LC3-I into LC3-II in a dose- and time-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:T47D, MCF-7 and Hela cells[1]
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Concentration:0-10 μM
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Incubation Time:72 hours
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Result:Displayed highly potent antiproliferative activity against T47D, MCF-7 and Hela cell lines with IC50 values of 0.91, 3.32 and 1.71 μM, respectively.
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Cell Line:GFP-LC3-HEK293[1]
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Concentration:40, 60 and 80 μM
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Incubation Time:0, 12, 24 and 36 hours
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Result:Significantly increased GFP-LC3 protein puncta with both dose- and time-dependent manners in HEK293 cells.
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Cell Line:Hela, T47D and HEK293[1]
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Concentration:0, 5, 10 and 20 μM in T47D and Hela; 0, 40, 60 and 80 μM in HEK293
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Incubation Time:0, 12, 24 and 36 hours
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Result:Increased the transformation of LC3-I into LC3-II in a dose-dependent manner, and enhanced the expression of LC3-II in a time-dependent manner.
Chemical Information
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CAS No. 2486455-03-0
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Appearance Solid
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Molecular Weight 531.64
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Formula C32H37NO6
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Color White to off-white
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SMILES
OC1=C(C2=CC(CC=C)=CC(C(N3CCOCC3)C4=CC(OC)=C(C(OC)=C4)OC)=C2O)C=C(CC=C)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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