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Cat. No.: HY-W509563

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Frataxin-IN-1

Frataxin-in-1 (Compound (+)-11) is a Frataxin inhibitor with IC₅₀ value of 45 μM, which can be used in the study of Friedreich's ataxia (FRDA).

For research use only. We do not sell to patients.

CAS No.: 102616-64-8
Formula: C₂₀H₂₃NO₆
Molecular Weight:373.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Frataxin-IN-1 Chemical Structure

CAS No.: 102616-64-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Frataxin-in-1 (Compound (+)-11) is a Frataxin inhibitor with IC₅₀ value of 45 μM, which can be used in the study of Friedreich's ataxia (FRDA)^[1].

IC₅₀ & Target

IC50: 45 μM (Frataxin)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Calu-6	IC₅₀	45 μM Compound: (+)-11,NSC38157	Inhibition of human His-tagged Frataxin/GST-tagged mono ubiquitin interaction expressed in human Calu6 cells after 3 days by GST pull down-based Western blot analysis Inhibition of human His-tagged Frataxin/GST-tagged mono ubiquitin interaction expressed in human Calu6 cells after 3 days by GST pull down-based Western blot analysis	[PMID: 23506486]
U-87MG ATCC	IC₅₀	32 μM Compound: 6a	Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after 72 hrs by MTT assay	[PMID: 32830969]

Chemical Information

CAS No. 102616-64-8
Molecular Weight 373.40
Formula C₂₀H₂₃NO₆
SMILES

COC1=CC=CC(=C1OC)C(C2=CC3=C(C=C2O)OCO3)N4CCOCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lavecchia A, et al. Discovery of a novel small molecule inhibitor targeting the frataxin/ubiquitin interaction via structure-based virtual screening and bioassays. J Med Chem. 2013 Apr 11;56(7):2861-73. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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